Previously we have shown that g-aminobutyric acid (GABA) is an inhibitory neurotransmitter restricting the pubertal increase in LHRH release in juvenile monkeys, and that interfering with GABA synthesis with an antisense oligodeoxynucleotide (AS) for glutamic acid decarboxylase (GAD67) mRNA results in an increase in LHRH release in prepubertal monkeys. GAD67 is a catalytic enzyme that synthesiz...

The responses of serum testosterone (T), 17 alpha-hydroxyprogesterone, and 17 beta-estradiol (E2) to four im injections of hCG (5000 IU/1.7 m2) given on days 0, 4, 7, and 10 were studied in 10 prepubertal and 10 pubertal boys with hypogonadotropic hypogonadism (groups O and P, respectively). Serum was obtained before each injection and on day 14. The results were compared with those of controls...

CONTEXT Cytotoxic treatment may accelerate depletion of the primordial follicle pool, leading to impaired fertility and premature menopause. Assessment of ovarian damage in prepubertal girls is not currently possible, but Anti-Müllerian Hormone (AMH) is a useful marker of ovarian reserve in adults. OBJECTIVE The objective of the study was to prospectively evaluate AMH measurement in children ...

BACKGROUND Height and adiposity track over childhood, but few studies, to our knowledge, have longitudinally examined the mediating relation of the timing and progression of puberty. OBJECTIVE We assessed interrelations between prepubertal height and body mass index, the progression through puberty, and young adult height and adiposity. METHODS We analyzed data from the Birth to Twenty Plus...

Major depressive disorder (MDD) is a debilitating illness that affects twice as many women than men postpuberty. This female bias is thought to be caused by greater heritability of MDD in women and increased vulnerability induced by female sex hormones. We tested this hypothesis by removing the ovaries from prepubertal Wistar Kyoto (WKY) more immobile (WMI) females, a genetic animal model of de...

Amaç: Büyüme hormonu (BH) eksikliği boy kısalığının en sık endokrinolojik nedenidir. Bu çalışmanın amacı idiyopatik büyüme (İBHE) tanısı alan çocukların klinik özellikleri ve tedaviye cevaplarının değerlendirilmesidir. Gereç Yöntemler: Olguların dosyaları retrospektif olarak değerlendirildi. tanı anındaki takvim yaşı (TY), antropometrik verileri, puberte evresi, hedef boyu, serum insülin benzer...

Plasma follicle-stimulating hormone (FSH) was evaluated in gilts from two studies in which ovulation rate was increased through direct selection for number of corpora lutea (CL) to determine whether selection for ovulation rate affected FSH secretion during prepubertal development. In the first study, 76 control and 110 selected gilts of University of Nebraska gene pool lines were bled twice du...

Sports talent may be identified from young children when they show interest in different sports. Anthropometric, physical, cardiorespiratory fitness and lipids profiles contribute to selection procedures. The present study was undertaken to investigate the anthropometric, physical, cardiorespiratiory fitness and lipids and lipoprotein profiles of 10-16 yrs children, in order to identify sports ...

BACKGROUND Celiac disease (CD) is an autoimmune enteropathy characterized by villus atrophy and malabsorption of essential nutrients. Vitamin D deficiency has been described in autoimmune diseases, but its status in prepubertal children with CD has not been adequately studied. OBJECTIVE To determine the vitamin D status of prepubertal children with CD. STUDY DESIGN A retrospective study of ...

BACKGROUND Resistin was first reported to be an adipocyte-specific hormone, but recent studies have indicated a connection between resistin and reproductive function. However, it is not yet known if resistin is expressed by the ovary and if it can affect steroidogenesis in ovarian follicles from prepubertal pigs. METHODS In this study, using real time PCR, immunoblotting, and ELISA, we quanti...