BACKGROUND There are still inconsistent conclusions about the association of prenatal alcohol drinking with congenital heart defects (CHDs). We conducted this meta-analysis to investigate the association between prenatal alcohol exposure and the risk of overall CHDs and the CHDs subtypes. METHODS Case-control and cohort studies published before March 2015 were searched through PubMed and Emba...

OBJECTIVE To test the effectiveness of a brief intervention in the reduction of prenatal alcohol consumption by women when a partner is included. METHODS Randomized trial of a single session brief intervention given by the study nurse or principal investigator for 304 pregnant women and their partners. The women had positive T-ACE (Tolerance, Annoyed, Cut down, Eye-opener, an alcohol screenin...

BACKGROUND Mercury is a global pollutant, and prenatal exposure is associated with adverse health effects. To date, no studies have evaluated the association between prenatal mercury exposure and DNA hydroxymethylation, an epigenetic modification important for tissue differentiation and embryonic development. OBJECTIVES We sought to evaluate the association between prenatal mercury exposure a...

BACKGROUND AND OBJECTIVE Prenatal diagnosis allows improved perioperative outcomes for fetuses with certain forms of congenital heart disease (CHD). Variability in prenatal diagnosis has been demonstrated in other countries, leading to efforts to improve fetal imaging protocols and access to care, but has not been examined across the United States. The objective was to evaluate national variati...

Pregnancy is the most challenging and happiest phase in every woman’s life which a mother through physical psychological changes. These changes will lead to discomforts pregnant women. can occur their third trimester of pregnancy, such as backache, leg cramps, pain pubic bones, false contraction, insomnia, breathing soreness, fatigue. Exercise that be done during pregnancy practicing techniques...

OBJECTIVES The objective of this study is to determine the prevalence of Chlamydia trachomatis and risk factors for positive repeat tests in a high-risk population presenting for early prenatal care. METHODS We completed a retrospective cohort study of 2,484 women who initiated prenatal care prior to 20 weeks gestation, delivered, and received testing for cervical C. trachomatis at Grady Memo...

OBJECTIVE To determine whether implementation of an electronic health record (EHR) would increase the rate of prenatal Human Immunodeficiency Virus (HIV) and purified protein derivative (PPD) testing. METHODS Eligible participants received prenatal care and delivered at term at a single academic institution in March-April 2011, March-April 2012, and March-April 2013. As part of routine prenat...

Previous studies have demonstrated the influence of changes in the age at which women give birth, and of developments in prenatal screening and diagnosis on the number of pregnancies diagnosed and terminated with chromosomal anomalies. However, we are unaware of any population studies examining pregnancy terminations after diagnosis of chromosomal anomalies that has included all aneuploidies an...

The objective was to investigate several aspects of the medical competence of general practitioners (GPs), gynaecologists (GYNs) and paediatricians (PEDs) by assessing their beliefs and self-perceived competence with regard to genetic testing. A questionnaire was sent to randomly selected GPs (n=200), GYNs (n=300) and PEDs (n=265). The response rate for GPs, GYNs and PEDs was 64%, 69% and 72%, ...

BACKGROUND Early diagnosis of critical congenital heart defects (CCHD) may be missed both during prenatal echocardiography and the short stay in the neonatal nursery, leading to circulatory collapse or death of the newborn before readmission to hospital. AIM To assess the usefulness of pulse oximetry as a screening test in early diagnosis of CCHD in newborns. METHODS A prospective screening...