background: premature rupture of membranes (prom) is a common obstetric issue during pregnancy which might lead to serious fetal or maternal problems. therefore, an appropriate diagnosis and management of prom are of significant importance in patients. objective: the aim of this study was to determine the accuracy of placental alpha microglobuline-1 (pamg-1) test in prom diagnosis and compare t...

BACKGROUND Accurate prediction of infection, including maternal chorioamnionitis and early-onset neonatal infection, remains a critical challenge in cases of preterm rupture of membranes and may influence obstetrical management. The aim of our study was to investigate the predictive value for early-onset neonatal infection and maternal histological and clinical chorioamnionitis of maternal biol...

Correspondence: Dr. Roxana Elena Bohîlţea e-mail: r.bohiltea@ yahoo.com Premature rupture of fetal membranes is associated with a substantial fetal morbidity and mortality. Immediate actions that can improve the future neonatal outcome are the administration of antenatal corticosteroid therapy, infection prophylaxis, tocolytic drugs and insurance of an appropriate neonatal nursery level. One of...

PURPOSE To assess whether hair-relaxer use is associated with an increased risk of preterm birth among African-American women. METHODS We used data from the Black Women's Health Study. The participants were enrolled in 1995 and provided follow-up information in 1997, 1999, and 2001. Among 6130 singleton births reported by women <45 years of age during follow-up, 497 were preterm (<37 weeks ge...

Fetal membrane rupture is associated with increased expression of matrix metalloproteinase-9 (MMP-9) and matrix degradation. We have determined the functional significance of a variable number tandem repeat and a single nucleotide polymorphism (SNP) in the MMP-9 gene on promoter activity and their association with preterm premature rupture of membranes (PPROM). The 14 CA-repeat allele was a str...

Spontaneous rupture of membranes before the onset of labor at term is commonly referred to as PROM (either premature or preterm rupture of membranes) and occurs in about 8% of term pregnancies. PROM is associated with an increased risk of infection. Many controversies exist regarding the optimal management of PROM, including the choice of induction or expectant management, use of digital vagina...

In many cases, the management of preterm PROM will be dictated by the presence of advanced labor, intrauterine infection, placental abruption, or nonreassuring fetal testing. These patients should be delivered expeditiously, with group B streptococcus prophylaxis given where possible, and cesarean delivery reserved for routine obstetric indications. The stable patient with PPROM and documented ...

INTRODUCTION Preterm premature rupture of membranes (PPROM) complicates 1-5 % of all pregnancies and is the major contributory factor for perinatal morbidity and mortality. Micronutrient deficiency (vitamin C) is associated with increased risk of PPROM. This study was conducted to establish the association between maternal plasma vitamin C concentration in women with PPROM and women without PPR...