Background Placentation shares many analogues with the development of tumors such as rapid proliferation, invasiveness, gene expression profiles especially the expression of tumor suppressor genes, oncogenes and matrixmetallo proteinases (MMPs). Thus, a placenta has been described as a pseudomalignant tissue. However, placentation is tightly regulated and any deregulation of this pseudomalignan...

early recognition of gestational trophoblastic neoplasm (gtn) will maximize the chances of cure with chemotherapy but some patients present with many different symptoms months or even years after the causative pregnancy making diagnosis difficult. clinicians should be aware of the possibility of gtn in any reproductive age woman with bizarre central nervous system, gastrointestinal, pulmonary s...

parathyroid hormone-related protein producing pancreatic neuroendocrine tumors have been infrequently reported. herein, we report a case of an iranian woman who had such a tumor during pregnancy, and gave birth to a female neonate with esophago-tracheal fistula and imperforated anus. hypercalcemia was diagnosed at postpartum because of elevated serum calcium levels in the neonate and neurologic...

pyogenic granuloma (pg) is a well-known benign non-neoplastic overgrowth. it is a response to mild irritation and might be related to hormonal factors and certain kinds of drugs. pg preferentially affects the gingiva, but can be found extragingivally with varying clinical features. the most common treatment is surgical excision. this article describes a case of extragingival pg occurring on the...

Using a preclinical model, we investigated whether excess estradiol (E2) or leptin during pregnancy affects maternal mammary tumorigenesis in rats initiated by administering carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) on day 50. Two weeks later, rats were mated, and pregnant dams were treated daily with 10 μg of 17β-estradiol, 15 μg of leptin, or vehicle from gestation day 8 to 19. Tumor d...

The co-occurrence of primary brain tumor and pregnancy poses unique challenges to the treating physician. If a rapidly growing lesion causes life-threatening mass effect, craniotomy for tumor debulking becomes urgent. The choice between awake craniotomy versus general anesthesia becomes complicated if the tumor is encroaching on eloquent brain because considerations pertinent to both patient sa...

PURPOSE Infertility is one of the less common presenting features associated with testicular tumors. We evaluated the histologic and biochemical findings, and pregnancy outcome in patients presenting with infertility who were found to have testicular tumors. METHODS Seven patients with infertility were found to have testicular cancer over a 15-year period. All patients had a testicular ultras...

A 32-year-old woman was admitted for termination of her 6-week pregnancy at her request. However, pelvic examination followed by transvaginal ultra-sonography (TVU) revealed an adnexal mass complicating pregnancy and requiring surgical intervention that was carried out after termination of pregnancy. At laparotomy, left salpingooophorectomy was performed and histologic examination revealed a le...

background: neuroblastoma is the most common tumor in infancy and wilms’ tumor is the most common malignant tumor of kidney in childhood. both the tumors are usually within the differential diagnosis of each other. this study compares the clinical manifestations, sex and age distribution of childhood wilms’ tumor and neuroblastoma at one of tehran children hospitals. materials and methods: the ...