The decrease of federal and state support threatens long-term sustainability of research in publicly supported academic health centers. In weathering these financial threats, research at the University of California, San Francisco (UCSF), has undergone 3 substantial changes: institutional salary support goes preferentially to senior faculty, whereas the young increasingly depend on grants; priv...

Electric energy storage systems such as batteries can significantly impact society in a variety of ways, including facilitating the widespread deployment of portable electronic devices, enabling the use of renewable energy generation for local off grid situations and providing the basis of highly efficient power grids integrated with energy production, large stationary batteries, and the excess...

Cancer research is drawing on the human genome project to develop new molecular-targeted treatments. This is an exciting but insufficient response to the growing, global burden of cancer, particularly as the projected increase in new cases in the coming decades is increasingly falling on developing countries. The world is not able to treat its way out of the cancer problem. However, the mechani...

This article focuses on the sessions in which basic science research was presented at the XVII International AIDS Conference (AIDS 2008). It also provides an analysis of basic science issues which generated significant discussion and debate at the conference and are likely to have implications for future laboratory and clinical research. Data presented at AIDS 2008 confirmed the speed with whic...

Nonrandomized comparative effectiveness studies contribute to clinical and biologic understanding of treatments by themselves, via subsequent confirmation in a more targeted randomized clinical trial, or through advances in basic science. Although methodological challenges and a lack of accepted principles to assess the quality of nonrandomized studies of comparative effectiveness have limited ...

policies and programs, even though children comprise a majority of public assistance recipients. In 1995, about twothirds of those receiving Aid to Families with Dependent Children each month were children.1 Moreover, key provisions in the most recent welfare legislation, the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA), have implications for children. Based ...

This paper reviews the development and application of paired muscle preparations, called duplex, for the investigation of mechanisms and consequences of intra-myocardial electro-mechanical heterogeneity. We illustrate the utility of the underlying combined experimental and computational approach for conceptual development and integration of basic science insight with clinically relevant setting...

Probably ever since the Flexner report endowed basic scientists with a central role in the education of doctors, the same basic scientists have been engaged in active, but circular, debates about why basic science really is essential to medical education. The arguments are generally at the theological level and can easily be dismissed by critics as self-serving. There is little evidence in the ...

This study investigated the relations among preservice elementary teachers’ ideas about evolution, their understanding of basic science concepts and college science coursework. Forty-two percent of 240 participants did not accept the theory of human evolution, but held inconsistent ideas about related topics, such as co-existence of humans and dinosaurs and plate tectonics. Accepting the theory...

A central activity of the Center for Negative Carbon Emissions is the demonstration of direct air capture technologies with machinery that can operate in open environments. Initially a major focus of the Center is on demonstrating air capture based on the humidity swing. However, work at the Center over time will consider other approaches as well. The demonstration requires a large engineering ...