We present a case of proton pump inhibitor-responsive eosinophilic esophagitis (PPI-REE) in a patient with severe dysphagia and markedly elevated baseline esophageal eosinophilia that was previously deemed unresponsive to PPI. Upon reintroduction to PPI therapy with monthly endoscopy and dilation over the course of 4 months, the patient improved clinically and resolved her mucosal eosinophilia....

Background: Evidence of patient and public involvement (PPI) in health research dissemination is weak and the development of mechanisms to assist the adoption and diffusion of PPI outcomes into research findings, patient experience and clinical practice is at an early stage. Aim: This paper seeks directly to address this weakness by increasing researchers’ awareness and understanding of the pot...

Prepulse inhibition (PPI) is a form of plasticity of the startle response in which presentation of a weak stimulus immediately before an intense startling stimulus reduces the resultant startle response. Deficits in PPI, an operational measure of sensorimotor gating, are observed in schizophrenia patients and can be modeled in rats by the psychotogen phencyclidine (PCP). PCP-induced deficits in...

In information sharing networks, having a privacy preserving index (or PPI) is critically important for providing efficient search on access controlled content across distributed providers while preserving privacy. An understudied problem for PPI techniques is how to provide controllable privacy preservation, given the innate difference of privacy of the different content and providers. In this...

The topology behind biological interaction networks has been studied for over a decade. Yet, there is no definite agreement on the theoretical models which best describe protein-protein interaction (PPI) networks. Such models are critical to quantifying the significance of any empirical observation regarding those networks. Here, we perform a comprehensive analysis of yeast PPI networks in orde...

The prediction of protein function is one of the most challenging problems in bioinformatics. Several studies have shown that the prediction using PPI is promising. However, the PPI data generated from highthroughput experiments are very noisy, which renders great challenges to the existing methods. In this paper, we propose an algorithm, MFC, to efficiently mine maximal frequent dense subgraph...

An enduring theme in the literature exploring patient and public involvement (PPI) in research has been the focus on evaluating impact, defined usually in terms of participants' practical contribution to enhancing research processes. By contrast, there has been less emphasis on the perspectives and experiences of those involved in PPI. Drawing on qualitative data with people involved in the Nat...