Cenobamate is a novel antiseizure medication approved by the U.S. Food and Drug Administration European Medicines Agency, offering new therapeutic option for drug-resistant focal onset seizures. exhibits dual-mode activity, inhibiting persistent sodium currents enhancing inhibitory GABAergic synaptic transmission through allosteric modulation, thereby contributing to its antiepileptic effects. ...

Feed costs represent greater than 50% of the costs of producing milk. Several practical strategies have been applied to help minimize costs, including reduced feed losses during storage, reduced shrink at feed out, and determining favorable pricing for commodity feeds. Much less attention has been directed towards improving feed efficiency in dairy cattle. Although recognized as an important co...

'Functional Food' is now a very popular term. The conceptual approach developed in the EU-founded FUFOSE (Functional Food Science in Europe) project is rather restrictive, making functional food a food product to be part of the usual dietary pattern. Functional food science that supports the development of functional foods is and must remain part of the science of nutrition. Finally, all that e...

Following a request from the Commission to the European Food Safety Authority, the Scientific Panel on Additives and Nutrient Sources added to Food was asked to provide a scientific opinion on the safety of inositol hexanicotinate (inositol hexaniacinate) added for nutritional purposes as a source of niacin (vitamin B3) in food supplements and on the bioavailability of nicotinic acid from this ...

The purpose of this study was to identify gender differences in sociability towards a stranger over time using the Interaction Rating Scale Advanced (IRSA) as a context-based practical index of social relationships. Participants were 44 adults who completed three 5-minute interaction sessions, during which they were observed and assessed using the IRSA. Results indicated that all IRSA scores ha...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 drug‑drug interactions (ddis) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly‑therapy, with a prevalence of 20‑40%. in particular, poly‑therapy increases the complexity of therapeutic management and thereby the risk of clinically important ddis, wh...

The use of digital technology in the form of health care apps has been on the increase. In the nutrition area, apps are now available with a view to lead to behavior change, helping individuals to reflect on their food choices and identify weak points in their dietary routine. The article seeks to evaluate user perception regarding the usability of the Digital Food Guide (DFG), which is a mobil...

The regulation of food packaging has, indeed, become a global subject as the world's commercial channels have broadened since World War II. The first comprehensive regulatory statute governing the area was the Food Additives Amendment of 1958 in the United States, a modification of the 1938 Federal Food, Drug, and Cosmetic Act. Germany, Italy, The Netherlands, and Belgium began regulatory activ...

The intake of a pelleted diet offered ad libitum to pregnant Merino ewes between the 90th and 140th days of pregnancy was influenced by their previous nutritional history and degree of body fatness. Marked compensatory intake occurred in previously ill-fed ewes whereas the intake of well-fed fat ewes carrying single foetuses declined slightly as pregnancy proceeded. The body weights of single f...

Purpose The popular perception of herb-drug and drug-nutrient interactions is that they are unintended and problematic. Actually, purposeful coadministration of therapeutic agents within a clinical strategy represents a valuable approach to complex and evolving patient-centered care. As individuals age, they are more likely to be prescribed pharmaceutical medications: many also take herbs and n...