the field of vaccinology provides excellent promises to control different infectious and non-infectious diseases. genetic immunization as a new tool in this area by using naked dna has been shown to induce humoral as well as cellular immune responses with high efficiency. this demonstrates the enormous potential of this strategy for vaccination purposes. dna vaccines have been widely used to de...

BACKGROUND Standardization of inactivated influenza vaccines by hemagglutinin (HA) content is performed by the single radial immunodiffusion (SRID) method. Regulatory agencies prepare, calibrate, and distribute SRID reagent standards necessary for testing of seasonal influenza vaccines, and a similar process is used to produce potency reagents for candidate pandemic influenza vaccines that are ...

objective: hydrostatic pressure is crucial component of cell environment and fundamental physical quantity, also it is the main factor of both cell integrity and function. pressure variation disorder, beyond physiological limits, may lead to pathological states. in this study, we examined the effect of hydrostatic pressure on apoptosis induction, viability, morphology, adhesion potency to subst...

The cancer potency of chloroethane was estimated from dose-response data of uterine tumors among female mice exposed by inhalation (NTP, 1989). The cancer potency estimate corresponds to the upper 95 percent confidence bound on the linear term of the multistage model fit to cancer dose-response data in experimental animals. The potency derivation takes into account body size differences between...

The cancer potency of polygeenan was estimated from dose-response data of colorectal tumors among male and female rats exposed orally (Wakabayashi et al., 1978). The cancer potency estimate corresponds to the upper 95 percent confidence bound on the linear term of the multistage model fit to cancer dose-response data in animals. The potency derivation takes into account body size differences be...

Using the default procedures outlined in Title 22 (California Code of Regulations, Section 12703), the Office of Environmental Health Hazard Assessment (OEHHA) derived a human cancer potency estimate of 12 (mg/kg-day) for tetranitromethane. The potency derivation takes into account body size differences between humans and experimental animals. The Proposition 65 “no significant risk level” (NSR...

The nicotinic acetylcholine receptors (nAChRs) are a family of closely related but pharmacologically distinct neurotransmitter-gated ion channels. They are therapeutic targets for a wide range of neurological disorders, and a key issue in drug development is selective targeting among the more than 20 subtypes of nAChRs that are known. The present work evaluates a proposed hydrogen bonding inter...

The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibilit...

The University of Mississippi has a contract with the National Institute on Drug Abuse (NIDA) to carry out a variety of research activities dealing with cannabis, including the Potency Monitoring (PM) program, which provides analytical potency data on cannabis preparations confiscated in the United States. This report provides data on 46,211 samples seized and analyzed by gas chromatography-fla...