نتایج جستجو برای: potassium transporters
تعداد نتایج: 99032 فیلتر نتایج به سال:
Cellular membranes act as signaling platforms and control solute transport. Membrane receptors, transporters, and enzymes communicate with intracellular processes through protein-protein interactions. Using a split-ubiquitin yeast two-hybrid screen that covers a test-space of 6.4 × 10(6) pairs, we identified 12,102 membrane/signaling protein interactions from Arabidopsis. Besides confirmation o...
In the structure of bovine F1-ATPase determined at 1.95-A resolution with crystals grown in the presence of ADP, 5'-adenylyl-imidodiphosphate, and azide, the azide anion interacts with the beta-phosphate of ADP and with residues in the ADP-binding catalytic subunit, betaDP. It occupies a position between the catalytically essential amino acids, beta-Lys-162 in the P loop and the "arginine finge...
The SLC22 family of transporters is mostly composed non-selective transporters, which are expressed highly in liver, kidney and intestine, playing a major role drug disposition. may be divided into three subfamilies based on the nature substrate transported: organic cations (OCTs), anions (OATs) zwiterrion/cations (OCTN). Membrane topology predicted to contain 12 TM domains with intracellular t...
Gitelman syndrome is a rare autosomal recessive hereditary salt-losing tubulopathy, that manifests as hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. It is caused by mutations in the solute carrier family 12(sodium/chloride transporters), member 3 (SLC12A3) gene encoding the thiazide-sensitive sodium chloride cotransporter channel (NCCT) in the distal convoluted tubule of th...
Ypi1 was discovered as an essential protein able to act as a regulatory subunit of the Saccharomyces cerevisiae type 1 protein phosphatase Glc7 and play a key role in mitosis. We show here that partial depletion of Ypi1 causes lithium sensitivity and that high levels of this protein confer a lithium-tolerant phenotype to yeast cells. Remarkably, this phenotype was independent of the role of Ypi...
Escherichia coli possesses a number of specific K(+) influx and efflux systems that maintain an appropriate intracellular K(+) concentration. Although regulatory mechanisms have been identified for a number of these transport systems, the exact mechanism through which K(+) concentration is sensed in the cell remains unknown. In this work we show that Kbp (K(+) binding protein, formerly YgaU), a...
Potassium (K(+)) is a major osmoticum of plant cells, and the vacuolar accumulation of this element is a especially crucial feature for plants under high-salt conditions. Emerging evidence indicates that cation/proton transporters of the NHX family are instrumental in the H(+)-linked K(+) transport that mediate active K(+) uptake at the tonoplast for the unequal partitioning of K(+) between vac...
The authors' researches have been focused on pathogenic, physiological and biochemical mechanisms in hypertension and diabetes. Studies on hypertension were performed using salt-sensitive hypertensive Dahl rats as compared with the corresponding normotensive rats. Especially, implication with mobilization of electrolytes such as sodium, potassium, calcium and magnesium in hypertension gave rise...
increasing incidence of central nervous system (cns) disorders has become a major challenge for both basic and clinical scientific society to develop novel therapeutic models for treatment. the knowledge of stem cells has added a new dimension in the research towards finding more appropriate targets responsible for the disease fate determination. as stem cell research is progressing day by day ...
The electric eel (Electrophorus electricus) is unusual among electric fishes because it has three pairs of electric organs that serve multiple biological functions: For navigation and communication, it emits continuous pulses of weak electric discharge (<1 V), but for predation and defense, it intermittently emits lethal strong electric discharges (10 to 600 V). We hypothesized that these two e...
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