A study of the effect of additional oral potassium on the low body potassium of seven patients with severe valvular heart disease showed that the potassium supplements were retained. After one month's treatment the exchangeable potassium was significantly increased, but the predicted value was not reached in any of the patients. There was no significant change in plasma potassium. These results...

A potassium loading study was performed in acutely nephrectomized rats to determine the extrarenal effects of diuretics on potassium tolerance. Four diuretics were evaluated: hydrochlorothiazide, furosemide, bumetanide, and spironolactone. Following an intravenous potassium load (0.17 mEq/100 g over one hour), plasma potassium concentration rose by 2.69 +/- 0.26 to 3.67 +/- 0.20 mEq/L in all gr...

Toktam Faal Rastegar was born in Quchan (Iran). She completed her B.Sc. in Chemistry in 2005 from Ferdowsi University, Mashhad. She was graduated from M.Sc. degree in Organic Chemistry from Bu-Ali Sina University (2008), Hamadan, Iran. She is currently Organic Chemistry Ph.D student under the supervision of Prof. A. Khazaei and Prof. M.A. Zolfigol in Department of Chemistry at Bu-Ali Sina Unive...

Toktam Faal Rastegar was born in Quchan (Iran). She completed her B.Sc. in Chemistry in 2005 from Ferdowsi University, Mashhad. She was graduated from M.Sc. degree in Organic Chemistry from Bu-Ali Sina University (2008), Hamadan, Iran. She is currently Organic Chemistry Ph.D student under the supervision of Prof. A. Khazaei and Prof. M.A. Zolfigol in Department of Chemistry at Bu-Ali Sina Unive...

Extra potassium supplements, spironolactone or amiloride were given for 5 months to forty-nine patients with heart failure who were taking furosemide and were in a steady state. Plasma potassium increased with all three treatments but there was no significant increase in total body potassium or red cell potassium. These findings together with other studies suggest that patients with heart failu...

The administration of potassium to hypotensive, potassium-deficient rats results in a prompt restoration of their lowered blood pressure to noimotensive levels. Similar repletion of the potassium deficit in adrenalectomized rats is only partially effective in restoring the blood pressure to noimotensive levels. The spontaneous retention of potassium which occurs in potassium-deficient rats foll...

BACKGROUND Cardiac surgery patients are commonly treated with diuretics, which can result in hypokalemia requiring potassium supplementation. OBJECTIVE Our objective was to determine whether cardiac surgery patients receiving therapy with potassium-wasting diuretics can safely and beneficially maintain serum potassium levels by eating potassium-rich foods. DESIGN A prospectively randomized ...

Neuronal excitability relies on inward sodium and outward potassium fluxes during action potentials. To prevent neuronal hyperexcitability, potassium ions have to be taken up quickly. However, the dynamics of the activity-dependent potassium fluxes and the molecular pathways underlying extracellular potassium homeostasis remain elusive. To decipher the specific and acute contribution of astrogl...

BACKGROUND Previously, we reported that elevated extracellular potassium concentration in vitro inhibited proliferation and migration of vascular smooth muscle cells, formation of free radical compounds by macrophages, and reduced platelet sensitivity to agonists. More recently, we described a reduction in neointimal proliferation after balloon angioplasty injury in the carotid arteries of rats...