Comment. Althoughhyphema isone of the most common early postoperative complications following trabeculectomy, to our knowledge, intralenticular collection of blood has not been previously reported. Because of the use of an operating microscope and the refinement of surgical techniques, lens injury during trabeculectomy has been infrequently reported. We hypothesized that there had been anterior...

Background/aim—It was previously reported that collagenous extracellular matrix (ECM) in human capsular opacification contained isoforms of transforming growth factor â (TGFâ). In the present study, the authors performed immunohistochemistry to examine whether ECM in human capsular opacification and in cultures of bovine lens epithelial cells (LECs) contained latent TGFâ binding protein-1 (LTBP...

P erforming cataract extraction in patients with zonular weakness presents many challenges and increases the risk of intraand postoperative complications. Capsular tension rings (CTRs) and other endocapsular support devices have been important management options for patients with significant zonulopathy. Hara et al1 and Nagamato and Bissen-Miyajima2 introduced the first endocapsular devices, bu...

PURPOSE To establish a novel, targeted lentivirus-mediated LEP503-HSV-tk/GCV suicide gene therapy system combined with all trans-retinoic acid (ATRA) for the inhibition of human lens epithelial cell (HLEC) proliferation and treatment of posterior capsular opacification (PCO) after cataract surgery; to estimate the enhancement of the bystander effect by ATRA; and to explore the role of Connexin4...

PURPOSE To establish a novel, targeted lentivirus-based HSV-tk (herpes simplex virus thymidine kinase)/GCV (ganciclovir) gene therapy system to inhibit lens epithelial cell proliferation for treatment of posterior capsular opacification (PCO) after cataract surgery. METHODS An enhanced Cre recombinase (Cre/loxP) system with a lentiviral vector expressing Cre under the control of the lens-spec...

J Babol Univ Med Sci; 18(12); Dec 2016; PP: 7-12 Received: Jun 2 2016, Revised: Jul 27 2016, Accepted: Sep 27 2016. ABSTRACT BACKGROUND AND OBJECTIVE: Nd:YAG laser posterior capsulotomy is a standard method for treatment of posterior capsule opacification (PCO) in adults. However, there is not enough information available regarding the advantages and disadvantages of its conventional techniques...

PURPOSE The aim of the present study was to examine the effects of the sigma-2 receptor agonist, siramesine, on morphology, growth, cell death, lysosomal function, and effects on extra-lysosomal proteolytic systems in human lens epithelial cells. METHODS Human lens epithelial cells in culture were exposed to siramesine and examined for morphological changes using Nomarski optics or calcein. L...

Shikonin is a compound from the herbal plant Lithospermum erythrorhizon that has been proved to possess powerful anti-proliferative effect on many kinds of cancers and to be safe in in vivo study. Posterior capsular opacification (PCO), the most frequent complication of cataract surgery, is mainly caused by the uncontrolled proliferation of retained human lens epithelial cells (HLEs). In this s...

BACKGROUND The aim of this study was to evaluate the impact of capsulorhexis diameter, localization and shape on posterior capsule opacification (PCO) development after cataract extraction with phacoemulsification. MATERIAL/METHODS We retrospectively analyzed of 297 patients who underwent phacoemulsification and AcrySof SA60AT implantation. In a first group of 97 patients, 53 received small c...