The tumor microenvironment is a milieu of heterogeneous architectural features that affect tumor growth and metastatic invasion. Pore size, density, stiffness, and fiber architecture change dramatically from location to location throughout the tumor matrix. While many studies have addressed the effects of two-dimensional extracellular matrix structure and composition on cell migration, less is ...

Potassium channels exhibit a modular design with distinct structural and functional domains; in particular, a highly conserved pore-loop sequence that determines their ionic selectivity. We now report the functional characterisation of a novel group of functionally non-selective members of the prokaryotic 'inward rectifier' subfamily of K(+) channels. These channels share all the key structural...

P2X receptors are trimeric cation channels with widespread roles in health and disease. The recent crystal structure of a P2X4 receptor provides a 3D view of their topology and architecture. A key unresolved issue is how ions gain access to the pore, because the structure reveals two different pathways within the extracellular domain. One of these is the central pathway spanning the entire leng...

The pore geometry of bioactive glass scaffolds intended for use in bone repair or replacement is one of the most important parameters that could determine the rate of bone regeneration. The pore geometry would also affect the mechanical properties of the scaffolds and their rate of degradation. Scaffolds with five different architectures, having ~50% porosity, were fabricated with silicate (13–...

Modified Moving Particle Semi-implicit (MMPS) is a particle-based method used to simulate pore-scale fluid flow through disordered porous media. We present a multi-GPU implementation of MMPS for hybrid CPU–GPU clusters using NVIDIA’s Compute Unified Device Architecture (CUDA). Message Passing Interface (MPI) functions are used to communicate between different nodes of the cluster and hence thei...

The combination of macro- and microporosity is a potent manner enhancing osteogenic potential, but the biological events leading to this increase in osteogenesis are not well understood. In study, we investigated effect dual pore size scaffold on physical properties, with hypothesis that cell condensation determining factor for enhanced differentiation. To end, hierarchical possessing (large sm...

conclusions the results suggest the important role of the antioxidant system potentiation in the prevention of myocardial damage. results cell degenerative changes, pyknotic nuclei, contraction bands, edema, and loosening of collagen in between muscle fibers were observed during ischemia-reperfusion. myocardial architecture and cellular morphology were recovered in co-administration groups, esp...

measurement of soil saturated hydraulic conductivity, ks, is normally affected by flow patterns such as macro pore; however, most current techniques do  not differentiate flow types, causing major problems in describing water and chemical flows within the soil matrix. this study compares eight models for scaling ks and predicted matrix and macro pore ks, using a database composed of 50 datasets...

OBJECTIVE To develop an integrated approach for engineering craniofacial scaffolds and to demonstrate that these engineered scaffolds would have mechanical properties in the range of craniofacial tissue and support bone regeneration for craniofacial reconstruction. EXPERIMENTAL VARIABLE Scaffold architecture designed to achieve desired elasticity and permeability. Scaffold external shape desi...