We compared the efficacy and tolerability of controlled-release carbamazepine (CBZ-CR) with conventional carbamazepine (CBZ) in 131 epileptic patients (both men and women, ages 6-65 years) in an open, multicentre, cross-over trial. Patients entered into the trial were previously on CBZ monotherapy or polytherapy. During the first 4 weeks, patients were treated with equivalent daily doses of CBZ...

In the care of patients, assessment use drugs is very imperative as it shows quality delivered to patients by caregivers. The study aimed compare prescription patterns antipsychotics in two public healthcare facilities Nigeria using a standardized World Health Organization instrument. studies were conducted at General Hospital, Offa (GHO), Kwara State, and Federal Neuropsychiatric Maiduguri (FN...

Case presentation: H.M.B.R., female, 5 years, mother with gestational diabetes. Birth weight of 4240 g, full term, APGAR 9/9, neonatal hypoglycemia as intercurrence. At the age 11 months and 14 days had her first epileptic seizure, being hospitalized treated phenobarbital, no effective response. Family history epilepsy. 2 years 8 months, was reassessed for worsening refractory epilepsy associat...

Women with epilepsy (WWE) have an increased risk of complications during pregnancy, which however can be minimized by optimal, interdisciplinary patient management. The aim of any therapy is to achieve an optimal balance between avoidance of seizures, which may be harmful to both mother and foetus, and minimization of foetal and neonatal exposure to deleterious influences of antiepileptic drugs...

Isolated Hemimegalencephaly (iHME) is a rare form of congenital malformation of cortical development.It is characterized by enlargement of all or part of one cerebral hemisphere. It typically presents with intractable seizures, mental retardation, developmental delay, contralateral hemiparesis and hemianopia. The patient was a five and half month's old baby girl who presented first with focal s...

Neuroleptic malignant syndrome (NMS) is the most dangerous life-threatening complication of antipsychotic medication. It's development is connected with the blockade of dopaminergic transmission (D2 receptors) in the nigrostriatal system of the brain. Fever is one of the main symptoms of this syndrome and it's elevation is due to the activation of the immune system. Numerous studies report that...

My Epilepsy Diary is a free Web-based application on the public website epilepsy.com, available for patients to track epilepsy and to aid clinicians with data-based, individualized management. The first aim of this descriptive study was to outline electronic diary functions. Second, the study retrospectively profiled a large cohort of 2010 calendar year diary users including demographics, seizu...

OBJECTIVES This article will review current data on the metabolism, interactions, methods of analysis, and adverse effects observed with the use of new anticonvulsant drugs. The role of the laboratory in the provision of therapeutic drug monitoring for these drugs is discussed. CONCLUSION Certain of the newer anticonvulsant drugs require therapeutic drug monitoring for their optimal use in th...

Although there is evidence of a growing awareness of the problem, no official policy statements or regulatory guidelines on polypharmacy have been released up to date by Italian Health Authorities. Medication review, application of appropriateness criteria and computerized prescription support systems are all possible approaches in order to improve the quality of prescribing in older persons. M...

BACKGROUND Diabetes mellitus may have profound effects on physical and emotional health and quality of life. OBJECTIVE The authors evaluated the perceived quality of life and its association with suicide risk in Italian patients with diabetes mellitus. METHOD Authors evaluated 100 patients with type 1 and type 2 diabetes. Patients completed the Beck Hopelessness Scale, the Suicide Score Sca...