The domain structures of the Escherichia coli Rep and Helicase II proteins and their ligand-dependent conformational changes have been examined by monitoring the sensitivity of these helicases to proteolysis by trypsin and chymotrypsin. Limited treatment of unliganded Rep protein (73 kDa) with trypsin results in cleavage at a single site in its carboxyl-terminal region, producing a 68-kDa polyp...

We have reported that dietary resistant starch (RS) reduces glucose-dependent insulinotropic polypeptide (GIP) mRNA levels along the jejunoileum in both normal and diabetic rats. In this study, we found that jejunal reduction of the GIP gene by feeding normal rats dietary RS was associated with decreases in histone H3 and H4 acetylation on the promoter/enhancer region of the gene.

Polypeptoids, with similar structure to polypeptides, are nowadays rising stars due their excellent solubility, processibility, enzymatic stability, and biocompatibility. Attractive properties of polypeptoid-containing copolymers endow them various applications in surface antifouling, biosensing, microreactor, drug delivery, stimuli–response. The syntheses block containing polypeptoids have att...

The Canadian Organization of Medical Physicists (COMP), in close partnership with the Canadian Partnership for Quality Radiotherapy (CPQR) has developed a series of Technical Quality Control (TQC) guidelines for radiation treatment equipment. These guidelines outline the performance objectives that equipment should meet in order to ensure an acceptable level of radiation treatment quality. The ...

The Japanese automobile manufacturer invented Lean Production or Toyota Production System (TPS) which has been introduced and implemented in Swedish manufacturers for around 20 years (Dabhilkar, et al., 2005). Many studies discussed how it creates success in optimizing production process and quality. However, many researches show that the gap between culture become the main barrier in the proce...

Networked learning is much more ambitious than previous approaches of using technology in education. It is, therefore, more difficult to evaluate the effectiveness and efficiency of the networked learning activities. Evaluation of learners’ interactions in networked learning environments is a resource and expertise demanding task. Educators participating in networked learning communities, have ...