Cytochrome P450 (CYP) enzymes are responsible for the metabolism of numerous xenobiotics and endogenous compounds, including the metabolic activation of most environmental toxic chemicals and carcinogens. Both metabolic and genetic polymorphisms have been identified for human CYP enzymes. The association of CYP genetic polymorphism and human cancer risk, and susceptibility to environmental haza...

The genomes of many marine invertebrates, including the purple sea urchin and the solitary ascidians Ciona intestinalis and Ciona savignyi, show exceptionally high levels of heterozygosity, implying that these populations are highly polymorphic. Analysis of the C. savignyi genome found little evidence to support an elevated mutation rate, but rather points to a large population size contributin...

Backgrounds: There is a wide range of individual responses to mycobacterium infection. However, the reason why certain people suffers from disease when they are infected with while others remain healthy still unknown. Genetic susceptibility thought be one important explanatory factors for individuals risk developing pulmonary tuberculosis (TB). FokI polymorphism was genetic variations within vi...

BACKGROUND In recent years, the PLCE1 rs2274223 polymorphism has been extensively investigated as a potential risk factor for upper gastrointestinal cancers, including squamous cell carcinoma (ESCC) and gastric cancer. However, the results of these studies have been inconsistent. METHODS A meta-analysis of 13 case-control studies was performed including more than 11,000 subjects with genotype...

Pearl millet (Pennisetum glaucum (L.) R. Br.) and napier grass (Pennisetum purpureum Schumach) are the most economically important species in the genus Pennisetum. Knowledge of genetic diversity of these two species would enhance their potentials for utilization. The present work assessed the genetic diversity and phylogenetic relationship among Nigerian and Indian accessions of pearl millet an...

The Argania is an endemic genetic resource in Morocco holding an important ecological and socio-economical benefit. However, overgrazing and overharvesting lead to a serious downturn in the number of trees. To characterize genetic diversity within and among 24 populations, represented by 240 argan trees, four combinations of SRAP primers and eight combinations of REMAP primers were used. A tota...

background: indigenous chickens could serve as precious genetic resources that should be considered in conservation and breeding programs. the major histocompatibility complex (mhc) has a strong association to disease resistance/susceptibility, production and reproduction traits in chicken. therefore, identifying its polymorphism in populations under selective breeding could be used for selecti...