background : progression of systemic lupus erythematosus (sle) could be due to oxidative stress especially through reactive oxygen species (ros). detoxification of ros is largely performed by glutathione s-transferases (gsts), therefore polymorphisms of gstm1, gstt1 and gstp1 genes which decrease enzymes activity could affect sle susceptibility. the aim of this study was to determine the effect...

abstract   background: the disrupted-in-schizophrenia 1 (disc1) gene, on the chromosome position 1q42, was initially identified at the breakpoint of a balanced translocation, t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large scottish family.   methods: our samples included 200 unrelated patients diagnosed with schizophrenia on the basis of dsm-iv criteria and 200 norm...

the restriction enzyme ava ii detects the base change of the intervening sequence ii (ivs ii) which is used as one of the markers of β-globin gene polymorphism. this study was conducted to determine the frequency of the ava ii site on the β-globin gene among normal people and patients with sickle cell syndrome (scs) in iran. dna fragments containing the ivs ii region of the β-globin gene from 3...

background: varicocele is associated with the failure of ipsilateral testicular growth and development, and the symptoms of pain and reduced fertility. the highly condensed structure of the sperm nuclear chromatin is provided by proper expression of transition nuclear protein (tnp) genes, so any dysregulational expression of these genes results in abnormal spermatogenesis and infertility. objec...

background : apolipoprotein e (apoe) gene encodes an important protein in reforming injuries of central nervous system (cns). it is assumed that various apoe alleles may be functionally different. the purpose of this study was to investigate the distribution of apoe genotypes in multiple sclerosis (ms) patients in a small cohort of iranians. methods : in this case-control study, blood samples o...

background the association between tumor necrosis factor-alpha (tnf-α) (-308 g/a) gene polymorphisms and level of tissue destruction and periodontal disease progression is not proved. objectives the present study investigated the stereological parameters of interdental papilla in chronic periodontitis (cp) patients with tnf-α (-308 g/a) gene polymorphisms. materials and methods sixty gingiva sa...

prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative disease by an entirely novel mechanism. the conformational change in prion proteins results in a change from a predominantly α-helical protein to a β-sheet form, which causes scrapie in sheep and goat. the present study was carried out to identify polymorphisms of the prion protein gene (prp) ...

skin cancer is one of the most important type of cancers in the world. in this way, molecular investigation in order to detect some novel mechanisms and polymorphisms involved in cancer development can be impressive and vital. in this way, the aim of this study was the histopathological investigation of skin cancer and its relationship with polymorphism of cdkn2a gene. this case-control study w...

aim : the aim of this study is to evaluate the polymorphism in bax gene and its association with some clinical pathology traits in gastric cancer.   background : gastric cancer is considered as the fourth most common cancer in the north and northwest of iran. bcl2 family has a key role in regulation of apoptosis, and any changes in the expression of bcl2 lead to cancer. patients and methods : b...

The GH gene and BMP15 gene have been used as candidate genes for ­marker-assisted selection in different livestock species. Random blood samples were obtained from 180 Zel sheep breed to study genetic polymorphism of these genes. DNA was extracted from blood samples and a 365 bp fragment from the exon V of the ovine growth hormone gene and a 312 bp region from exon II of BMP15 gene were amplifi...