osteoporosis is a metabolic bone disease affecting mostly elderly women. as metabolizing enzymes, the roles of few cytochromes have been studied in osteoporosis development. the aim of this study was to assess for the first time the association of cyp2e1 and cyp1a1 polymorphisms and osteoporosis in postmenopausal women. 112 postmenopausal women presenting osteoporosis and 93 age and sex matched...

background : to determine the frequency of the single nucleotide polymorphism m287t in exon 9 of the as3mt gene in iranian population and to assess the difference in allele frequencies with other ethnicities. subjects and methods : genotyping analysis was performed on 150 healthy subjects using the pcr-rflp assay. we used chi-square analysis to check the deviation from hardy–weinberg equilibriu...

background: acromegaly is associated with increased morbidity and mortality related to cardiovascular diseases. leptin (lep) and leptin receptor (lepr) gene polymorphisms can increase cardiovascular risks. the aim of this study was to investigate association between the frequencies of lep and lepr gene polymorphisms and subclinical atherosclerosis in acromegalic patients. methods: forty-four ac...

obesity is currently considered as a serious global health problem which is influenced by environmental and genetic factors. association of genetic variants with obesity is widely scrutinized in recent years. the aim of this study was to evaluate present data on genetics of obesity in iranian population in a systematic review study. to obtain all related studies, google scholar, pubmed, and per...

tap1 and tap2 genes encode heterodimeric molecule involved in endogenous antigen processing. the present study was undertaken to find out the possible association between tap1 and tap2 polymorphisms and risk of pulmonary tuberculosis (ptb) in a sample of iranian population. polymorphisms of tap1 (rs1057141, rs1135216) and tap2 (rs2228396, rs241447, rs67511411, rs141555015) were determined in 17...

macrophages and t-lymphocytes are involved in immune response to mycobacterium tuberculosis. macrophage produces interleukin (il)-1 as an inflammatory mediator. il-1 receptor antagonist (il1-ra) is a natural antagonist of il-1 receptors. in this study we aimed to examine the possible association between the variable number of tandem repeats (vntr) of the il-1 receptor antagonist (il1rn) gene an...

the results of many studies suggested possible relationship between polymorphism at codons 16 and 27 and development of tolerance to beta-2 adrenoceptor agonist responses as well as disease severity in asthmatic patients. this study was designed to evaluate the effect of polymorphism of beta2 adrenoceptors on response to salmeterol and fluticasone (as inhaled seretide). sixty-four patients with...

c3 typing was performed, by agarose gel electrophorisis, in 147 german patients suffering from hyperlipoproteinemia. the control group consisted of 322 healthy germans. high frequencies of non-typeable sera, varying between 16.66 and 35.71% in different hlp types, found in the present investigation are notable and are a clue for chemical denaturation of c3 protein in hlp patients. statistical a...

introduction: association between single-nucleotide polymorphisms (snps) in mu opioid receptor gene and drug addiction has been shown in various studies. here, we have evaluated the existence of polymorphisms in exon 3 of this gene in iranian population and investigated the possible association between these mutations and opioid addiction.  methods: 79 opioid-dependent subjects (55 males, 24 fe...