The state of adsorbed protein molecules can be examined by comparing the shifts in a narrow line resonance wavelength of transverse electric (TE) and transverse magnetic (TM) whispering gallery modes (WGM) when the molecules adsorb onto a transparent microsphere that houses WGM. In adsorption of bovine serum albumin (BSA) onto an aminopropyl-modified silica microsphere, the TM/TE shift ratio in...

We show that by magnetically trapping a superconducting microsphere close to a quantum circuit, it is possible to perform ground-state cooling and prepare quantum superpositions of the center-of-mass motion of the microsphere. Due to the absence of clamping losses and time-dependent electromagnetic fields, the mechanical motion of micrometer-sized metallic spheres in the Meissner state is predi...

The long-term durability of polyethylene lining total hip arthroplasty (THA) mainly depends on periprosthetic osteolysis due to wear particles, especially in young active patients. In hip simulator study, reports revealed significant wear reduction of the alumina ceramic-on-polyethylene articulation of THA compared with metal-on-polyethylene bearing surfaces. However, medium to long-term clinic...

High fluences inside cavity ring-down spectroscopy optical resonators lend themselves to fluorescence or Raman spectroscopy. An instrument at 488 nm was developed to measure extinction, and fluorescence of aerosols. A detection limit of 6 x 10;-9 cm;-1Hz;-1/2 (0.6 Mm;-1Hz;-1/2) was achieved. The fluorescence spectral power collected from a single fluorescent microsphere was 10 to 20 pW/nm. This...

Whispering-gallery modes (WGMs) on Nd3+-doped glass microspheres with a radius of ∼15 μm were measured in a modified confocal microscope, where a dual spatial resolution in both excitation and detection zones was possible. As an alternative to the standard excitation mechanism by an evanescent wave, we used an efficient pumping/detecting scheme, focusing a laser in the microsphere and exciting ...

The appearance of a Nano-jet in the microsphere optical experiments is analyzed by relating this effect to non-diffracting Bessel beams. By inserting a circular aperture with a radius of subwavelength dimension in the EM waist, and sending the transmitted light into a confocal microscope, the EM oscillations by the different Bessel beams are avoided. On this constant EM field evanescent waves a...

Emerging viral diseases are a major problem to human and veterinary public health and continue to be an eminent threat to the world economy. Fluorescent microsphere immunoassay (FMIA) can be used for the detection of emerging infectious diseases in humans and animals. FMIA is a novel molecular diagnostic technology for the detection of antibodies to at least 100 target antigens in a small sampl...

This paper presents an on-chip biosensor using a polystyrene fluorescent microsphere as an optical resonator to enhance the fluorescence emission. The microsphere is attached on the wall of a microchannel in a polydimethylsiloxane (PDMS) optofluidic chip and excited by a focused laser beam using a confocal Raman microscope system. Based on the shift of Whispering Gallery modes (WGMs), this sens...

Power-spectral-density measurements of any sampled signal are typically restricted by both acquisition rate and frequency response limitations of instruments, which can be particularly prohibitive for video-based measurements. We have developed a new method called intensity modulation spectral analysis that circumvents these limitations, dramatically extending the effective detection bandwidth....

We demonstrate scaffolding of plasmonic nanoparticles by topological defects induced by colloidal microspheres to match their surface boundary conditions with a uniform far-field alignment in a liquid crystal host. Displacing energetically costly liquid crystal regions of reduced order, anisotropic nanoparticles with concave or convex shapes not only stably localize in defects but also self-ori...