Pyrrole-imidazole (Py-Im) polyamides can bind to the predetermined base pairs in the minor groove of double-helical DNA with high affinity. These synthetic small molecules can interfere with transcription factor-DNA interaction and inhibit or activate the transcription of corresponding genes. In the present study, we designed and synthesized a Py-Im polyamide to target 545 to 539 base pairs of ...

This study examines properties of the cotton/polyamide plain plated commercial socks (CO 81%/PA 19%) and pure polyamide fabric subjected to multifunctional treatment by a sol-gel coating technique where tetraethyl-orthosilicate (TEOS) zinc acetate dihydrate (ZAD) were used as precursors. Commercially available sock is produced on single cylinder knitting machine which results in two surfaces (c...

A new upper limit of binding site size is defined for the hairpin polyamide-DNA motif. Ten-ring hairpin polyamides containing pyrrole (Py) and imidazole (Im) amino acids were designed for recognition of seven base pair (bp) sequences in the minor groove of DNA. The DNA binding properties of two polyamides, ImPyPyPyPyγ-ImPyPyPyPy-â-Dp, and ImImPyPyPy-γ-ImPyPyPyPy-â-Dp were analyzed by footprinti...

Polyamide 6 films were aged in two environments inducing either only oxidation or hydrolysis of the polymer for up to years. Ageing temperatures ranged from 80°C 140°C. Samples characterized periodically terms both chemical structure at macromolecular scale, using SEC, DSC, SASX and WAXS, mechanical behaviour through tensile tests. Both degradation mechanisms lead chain scission within polymer,...