Tissue engineering is a rapidly advancing technology in the field of regenerative medicine. For the transplantation of cell sheets, a carrier must maintain the shape of a cell sheet from a culture dish to affected sites as well as release the sheet easily onto the lesion. In this study, we examined the utility of a novel, poly(lactic acid)-based carrier for cell sheets transplantation to the co...

Polycondensation and ring-opening polymerization are two important polymer synthesis methods. Poly(lactic acid), the most typical biodegradable polymer, has been researched extensively from 1900s. It is of significant importance to have an up-to-date review on the recent improvement in techniques for biodegradable polymers. This review takes poly(lactic acid) as the example to present newly dev...

The application of poly(lactic acid) for sustained protein delivery is restricted by the harsh pH inside carriers. In this study, we synthesized a pH-responsive comb-shaped block copolymer, polyethylene glycol monomethyl ether-ε-polylysine-g-poly (lactic acid) (PEP)to deliver protein (bovine serum albumin (BSA)). The PEP nanoparticles could automatically adjust the internal pH to a milder level...

Poly (lactic-co-glycolic) acid microspheres are amenable to a number of biomedical procedures that support delivery of cells, drugs, peptides or genes. Hydrophilisation or wetting of poly (lactic-co-glycolic) acid are an important pre-requisites for attachment of cells and can be achieved via exposure to plasma oxygen or nitrogen, surface hydrolysis with NaOH or chloric acid, immersion in ethan...

The effects of aqueous and deuterium oxide (D2O) solutions alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol) on the thermomechanical properties poly(lactic acid)—PLA—films were assessed by dynamic mechanical analysis. glass transition temperature (Tg) PLA films immersed in 25%, 50%, 75%, 100% (v/v) alcoholic compared with Tg water D2O. methanol ethanol decreased as concentration a...

Current biotechnology and sensor research has enhanced the drive to establish viable methods for depositing high-quality polymer thin films. In this research, thin films of poly methyl methacrylate PMMA were prepared by matrix-assisted pulsed-laser evaporation MAPLE . Up to 2 wt % of carbon nanotubes were subsequently added to MAPLE target systems for deposition of polymer nanocomposite films. ...

Objective(s): The current study reports the production and biocompatibility evaluation of a ternary nanocomposite consisting of HA, PLA, and gelatin for biomedical application.Materials and Methods: Hydroxyapatite nanopowder (HA: Ca10(PO4)6(OH)2) was produced by burning the bovine cortical bone within the temperature range of 350-450 oC followed by heating in an oven at 800. Synthesis of the te...

Abstract The present research investigates the hydrolytic degradation of ternary blends composed poly(ethylene- co -vinylacetate) (EVA), poly(lactic acid) (PLA), and poly(styrene- -methyl methacrylate)(poly(S- -MMA) (SMMA) (EPS) at a temperature 37 °C pH 7.4, monitoring changes in phosphate buffer solution for 6 months. In addition, mechanical behavior morphology were evaluated from comparison ...