1. To review the mechanisms and eff ects of opioids, cannabinoids, and topical agents in neuropathic pain. 2. To review clinically relevant pharmacokinetics and pharmacodynamics of opioids, cannabinoids, and topical agents in patients with neuropathic pain. 3. To review the clinical evidence for the use of opi-oids, cannabinoids, and topical agents in neuro-pathic pain.

The paper evaluates the contents of total forms of selected heavy metals (Zn, Cu, Ni and Pb) as well as the activity of catalase (CAT), dehydrogenases (DEH), alkaline phosphatase (AlP) and acid phosphatase (AcP) in mineral surface horizons of forest soils exposed to the effect of road traffic pollutions. The sampling locations (n = 24) were determined in the area covered by the Szubin Forest al...

Human land uses and population growth represent major global threats to biodiversity and ecosystem services. Understanding how biological communities respond to multiple drivers of human-induced environmental change is fundamental for conserving ecosystems and remediating degraded habitats. Here, we used a replicated 'real-world experiment' to study the responses of invertebrate communities to ...

The sexual stages of malarial parasites are essential for the mosquito transmission of the disease and therefore are the focus of transmission-blocking drug and vaccine development. In order to better understand genes important to the sexual development process, the transcriptomes of high-purity stage I-V Plasmodium falciparum gametocytes were comprehensively profiled using a full-genome high-d...

The objective of the study was to determine whether long-term metal pollution affects communities of epigeal spiders (Aranea), studied at three taxonomic levels: species, genera, and families. Biodiversity was defined by three indices: the Hierarchical Richness Index (HRI), Margalef index (D(M)) and Pielou evenness index (J). In different ways the indices describe taxa richness and the distribu...

This paper develops an index of pollution based on the epidemiological dose-response function associated with each pollutant, and the welfare losses due to exposure to pollution. The probability of damage is translated into welfare losses, which provides the common metric required for aggregation. Isopollution surfaces may then be used to compare environmental quality over time and space. An Ai...

earthworms are an important part of food chain in soil ecosystem. in polluted soils, heavy metals are consumed by earthworms and transferred to other organisms through food chain, resulting in many adverse health impacts. due to the benefits of earthworms for soil fertility, it is important to assess the effects of soil pollution on population, biomass and functions of earthworms. to determine ...

as opposed to the staining of non-cultivatable organisms of these two genera. Cotton gauze and rayon-polypropylene fiber swabs were equally sensitive for collecting salmonellae from the streams examined. Tetrathionate enrichment incubated at 41.5 C appeared to be superior to selenite-cystine for isolation of salmonellae from surface waters. Twenty-eight serotypes of Salmonella and two serotypes...

Air pollution is a global environmental issue, and there an urgent need for sustainable remediation techniques. Thus, phytoremediation has become popular approach to air remediation. This paper reviewed 28 eco-friendly indigenous plants based on both the tolerance index (APTI) anticipated performance (API), using level indices evaluate potential of most plant species control. The estimated APTI...