RATIONALE Nasal allergen provocations may be useful in investigating the pathophysiology of allergic rhinitis and effects of treatments. OBJECTIVE To use grass pollen nasal allergen challenge (NAC) to investigate the effects of allergen immunotherapy in a cross-sectional study. METHODS We studied nasal and cutaneous responses in untreated subjects with seasonal grass-pollen allergic rhiniti...

The results of our third trial on epicutaneous allergen-specific immunotherapy (EPIT) will be presented and discussed in the context of our previous trials. This monocentric, placebo-controlled, double-blind phase I/IIa trial included 98 patients with grass pollen rhinoconjunctivitis. Prior to the pollen season 2009, patients received six patches (allergen extract: n = 48; placebo: n = 50) with...

The immune response of atopic individuals against allergens is characterized by increased levels of Th2 cytokines and chemokines. However, the way in which the cytokine/chemokine profile is matched to the type of invading allergen, and why these profiles sometimes derail and lead to disease, is not well understood. We recently demonstrated that pollen modulates dendritic cell (DC) function in a...

air pollutants are reported to increase the specific ige response to allergens. to study allergen proteins and determine the effect of air pollutants on the allergenic potential of pollen extracts, the extracts were injected intraperitoneally and subcutaneously in guinea pigs. the results were analyzed by skin prick test (spt), elisa and sds-page followed by immunoblotting. the pollen extract o...

BACKGROUND In allergic individuals, onset of symptoms is related to atmospheric pollen grain counts and aeroallergen concentrations. However, this relationship is not always clear. OBJECTIVES To analyze the correlation between grass pollen grain and aeroallergen concentrations in Ciudad Real, Spain, during the year 2004 and establish their association with symptoms in patients with allergic a...

INTRODUCTION A pathomechanism of allergic rhinitis is complex. A neurogenic mechanism seems to play a significant role in this phenomenon. AIM The evaluation of influence of specific immunotherapy of mugwort pollen allergic patients on the bradykinin concentration in the nasal lavage fluid. MATERIAL AND METHODS The study included 22 seasonal allergic rhinitis patients. Thirty persons with m...

3. Blazowski L. Anaphylactic shock because of sublingual immunotherapy overdose during third year of maintenance dose. Allergy. 2008;63:374. 4. de Groot H, Bijl A. Anaphylactic reaction after the first dose of sublingual immuno-therapy with grass pollen tablet. Allergy. 2009;64:963--4. 5. Dunsky EH, Goldstein MF, Dvorin DJ, Belecanech GA. Anaphylaxis to sublingual immunotherapy. Allergy. 2006;6...

Allergen immunotherapy (AIT) is a guidelines-approved, disease-modifying treatment option for respiratory allergies, including allergic rhinitis (AR) induced by pollen. The various AIT regimens employed to date in pollen-induced AR can be classified as continuous (i.e. year-round) or discontinuous (i.e. pre-seasonal alone, co-seasonal alone or pre- and co-seasonal). Pre-and co-seasonal regimens...

Background Studies show that proallergic TH2 cells decrease after successful allergen-specific immunotherapy (AIT). It is likely iatrogenic administration of allergens drives these to exhaustion due chronic T-cell receptor stimulation. This study aimed investigate the T in connection with allergen exposure during AIT mice and two independent patient cohorts. Methods OVA-sensitized C57BL/6J were...

BackgroundWhether long-term exposure air to pollution has effects on allergic sensitization is controversial.ObjectiveOur aim was investigate associations of at birth and the time later biosampling with IgE against common food inhalant allergens, or specific allergen molecules, in children aged up 16 years.MethodsA total 6163 from 4 European cohorts participating Mechanisms Development ALLergy ...