Experiments show that the resting ouabain-insensitive sodium efflux in giant fibers from the barnacle Balanus nubilus is stimulated by external application of pentachlorophenol (PCP). This work has now been extended to include a study of muscle fibers preloaded with the Ca2+ indicator aequorin to determine whether PCP is able to increase light emission; and whether its potency depends on the nu...

Previous reports demonstrated that microcystin and related cyanobacteria polypeptides are rapidly cleared from plasma and accumulate in liver tissue. In the present study, we have used their ability to inhibit protein phosphatases to show that these cyanobacteria hepatotoxins are excreted into the bile of experimentally poisoned rainbow trout. At various times after oral administration of hepat...

Poisoned patients are managed by supportive measures and/or by the use of specific antidotes. Antidotes can offer significant advantages over supportive measures alone in many poisoned patients. The term ‘antidote’ is used to refer to any agent used to chelate the toxin, enhance its elimination, neutralize its effect, or ameliorate future complications, rather than just a pure pharmacological a...

The effect of endotoxin on the body temperature of mice was studied in animals housed without bedding at an environmental temperature of 15 C. Rectal temperatures were measured during the initial 3 to 5 hr of exposure. Doses of endotoxin ranging from 0.01 to 1 ld(50), as determined for mice maintained at 25 C, produce a hypothermia in proportion to dose. Concurrent injection of tryptophan magni...

Introduction:Poisoning is a common reasons for hospitalization in all over the world and exhausts a substantial share of health resources.Khoramabad is a rather large city in Iran but there has been no study about incidence of poisoned patients especially grave ones who are hospitalized in ICUs, thus we designed this study to epidemiologicall assess these patients in two major referral centers...

Over half the patients who were admitted to hospital after self-poisoning had seen their general practitioner in the previous month, and in half of those discharged from hospital no definite after-care arrangements were made. Opportunities for prevention of occurrences are being missed. Thorough follow-up of 135 such patients identified many non-medical problems, and over 80 per cent were helpe...

BACKGROUND Clinicians are often challenged to manage critically ill poison patients. The clinical effects encountered in poisoned patients are dependent on numerous variables, such as the dose, the length of exposure time, and the pre-existing health of the patient. The goal of this article is to introduce the basic concepts for evaluation of poisoned patients and review the appropriate managem...

A cross-sectional medical survey was conducted among 63 Nicaraguan aviation mechanics exposed to organophosphate and other toxic pesticides. Thirty-one (49 percent) reported having been acutely poisoned on the job. Also, seven of 14 novice mechanics, with less than one year on the job, reported that they had been poisoned. Thirty-eight (61 percent) had cholinesterase levels below the lower limi...

Background: Knowing the pattern of carbon monoxide (CO) poisoning in each region is vital for enhanced health planning. This study was designed to evaluate the epidemiologic pattern of unintentional acute CO poisoning in major cities of Fars province, southwest of Iran.  Methods: This one-year cross-sectional study was carried out on unintentional CO poisoning incidents in Fars province, Iran,...

3. Liver mitochondria isolated after suspension in 5 mM-sodium salicylate in 0-44m-sucrose carried out oxidative phosphorylation nearly as efficiently as the controls. 4. Salicylate was taken up by mitochondria at 00, but the binding was extremely labile. From 78 to 95 % of the salicylate taken up was removed by one rapid wash in sucrose medium. 5. The intracellular fluid of the livers of sailc...