Literature regarding acute human toxicity of thiopurines is limited to a handful of case reports. Our objectives were to describe all cases of overdose with thiopurines reported to the Swiss Toxicological Information Centre between 1995-2013. A retrospective analysis was performed to determine circumstances, magnitude, management and outcome of overdose with these substances. A total of 40 case...

INTRODUCTION Poisoning is an increasingly important cause of injury in the United States. In 2009 poison centers received 2,479,355 exposure reports, underscoring the role of poison centers in intentional and unintentional injury prevention. Antiretroviral (ARV) agents are commonly prescribed drugs known to cause toxicity, yet the frequency of these incidents is unknown. The objectives of this ...

BACKGROUND The incidence and spectrum of acute poisonings in South Africa are unknown. Poisoning data can be derived from sources such as hospital admission records and poison information centre (PIC) records. OBJECTIVES This study was conducted to examine the extent of the problem and to identify trends and toxicovigilance issues using PIC data. METHODS A survey was conducted based on Tyge...

INTRODUCTION N-benzylmethoxy (NBOMe) is a new class of hallucinogenic designer drugs sold on cheap blotter papers. They are potent 5-hydroxytryptamine-2A-receptor agonists, and since their recent entry into the drug market there have been worldwide reports of severe intoxications and even fatalities. This study reviews suspected NBOMe drug exposures reported to the Danish Poison Information Cen...

Consumption of online services and cloud computing offerings is on the rise, largely due to compelling advantages over traditional local applications. From a user perspective, these include zero-maintenance of software, the always-on nature of such services, mashups of different applications and the networking effect with other users. Associated disadvantages are known, but effective means and ...

Introduction In 2010, there were 4,796 snake bite exposures reported to Poison Centers nationwide (1). Health care providers frequently request help from poison centers regarding snake envenomations due to the unpredictability and complexity of prognosis and treatment. The Missouri Poison Center (MoPC) maintains a surveillance database keeping track of every phone call received. ESSENCE, a synd...

Family physicians often manage substance ingestions in children, most of which are nontoxic in nature. Physicians should know the phone number of the poison control center, understand the appropriate initial assessment of suspected toxin ingestion, and recognize important toxidromes. Rapid triage is crucial, including airway, respiration, and circulation stabilization. Appropriate supportive or...

Control of rabbits, Oryctolagus cuniculus, by poisoned bait has been widely practiced in Australia and New Zealand for many years. Since the 1950s, Compound 1080 has been the active ingredient and yielded good results (ca 90% kills) when first used. Recent trails (1973-74) in New Zealand showed that the main reason for poor results obtained nowadays is the failure of many rabbits to eat bait. R...

Introduction NPDS is a near real-time surveillance system and national database operated by the American Association of Poison Control Centers. NPDS receives records of all calls made to the 55 regional US poison centers (PCs). The Centers for Disease Control and Prevention (CDC) use NPDS to 1) provide public health surveillance for chemical, radiological and biological exposures and illnesses,...