Background The development and characterization of biomarkers abnormalities in Alzheimer’s disease (AD) animal models is particularly important for the investigation pathophysiological mechanisms drug development. With this mind, here, we aimed at characterizing brain glucose metabolism, indexed by [18F]FDG-microPET, TgF344-AD rat, a model harboring human APP/PS1 mutations. We hypothesized earl...

objective: resistance of metastatic lymph nodes (lns) to high dose i-131 therapy is associated with high morbidity in patients with differentiated thyroid cancer. we evaluated the role of f-18 fdg pet/ct in the prediction of resistance to high dose i-131 therapy in patients with papillary thyroid cancer. methods: the subjects were 307 patients who underwent total or near total thyroidectomy fol...

UNLABELLED To be a reliable predictor of response, tracer uptake should reflect changes in the amount of active tumor cells. However, uptake of (18)F-FDG, the most commonly used PET tracer, is disturbed by the inflammatory cells that appear early after cytotoxic therapy. The first aim of this study was to investigate whether 3'-(18)F-fluoro-3'-deoxy-l-thymidine ((18)F-FLT), a marker of cellular...

UNLABELLED (18)F-FDG, a marker of the enhanced metabolism characteristic of activated inflammatory cells, and (99m)Tc-annexin A5, a marker of apoptosis, are both widely believed to be useful for the imaging of unstable atheroma (rupture-prone vulnerable plaques [VP]). Serum cholesterol functions as a proinflammatory factor, driving the formation of VP, and affects the immune responses of aortic...

We report a case of an 85-year-old woman with a foreign-body granuloma which accumulated 18F-fluorodeoxyglucose (FDG). Unenhanced computed tomography showed a hyperdense mass with a hypodense rim in the right subphrenic space. FDG PET/CT images showed intense FDG uptake in the hypodense rim and little FDG uptake in the center of the mass, showing a ring-shaped appearance. The fusion imaging of ...

18F-fluorodeoxyglucose ([18F]-FDG) positron emission tomography/computed tomography (PET/CT) is a useful functional image technique to evaluate the disease extent in many cancers, as well differentiate benign from malignant metastasis. We report case of 49-year-old woman with breast cancer and suspected lung metastasis by conventional images. After FDG-PET/CT demonstrating faint, or even no FDG...

UNLABELLED In patients with inflammatory bowel disease (IBD) and in murine IBD models, mucosal disease activity is routinely assessed by endoscopy and histologic evaluation. This information is valuable for monitoring treatment response, with mucosal healing being a major treatment goal. The aim of this study was to evaluate the translational potential of noninvasive (18)F-FDG PET/CT for the as...

UNLABELLED The aim of this study was to evaluate the potential role of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in patients with unexplained rising serum alpha-fetoprotein (AFP) levels after the treatment of hepatocellular carcinoma (HCC). PATIENTS AND METHODS Thirty-one FDG-PET studies were performed in 26 patients (age range, 45-83; 21 men and 5 women), who had u...

Abstract Purpose While radiotherapy (RT) for head and neck cancer (HNC) has made recent strides, RT-induced vasculitis continues to adversely affect long-term patient outcomes. Guidelines managing this complication remain scarce, supporting the need a sensitive imaging modality in post-treatment evaluations. In review, we discuss current literature regarding 18 F-fluorodeoxyglucose positron emi...