نتایج جستجو برای: plga nanosphere

تعداد نتایج: 4541  

2013
Kai Zhao Wei Li Tingting Huang Xiaomei Luo Gang Chen Yang Zhang Chen Guo Chunxiao Dai Zheng Jin Yan Zhao Hongyu Cui Yunfeng Wang

BACKGROUND Although the Newcastle disease virus (NDV) inactivated vaccines and attenuated live vaccines have been used to prevent and control Newcastle disease (ND) for years, there are some disadvantages. Recently, newly developed DNA vaccines have the potential to overcome these disadvantages. The low delivery efficiency, however, hindered the application of DNA vaccines for ND in practice. ...

Journal: :The Journal of antimicrobial chemotherapy 2004
Sandra Prior Bruno Gander Concepción Lecároz Juan M Irache Carlos Gamazo

OBJECTIVES The intracellular antibiotic efficiency of gentamicin-loaded microspheres in the context of Brucella-infected murine monocytes was examined in vitro with a view to developing improved therapies for the treatment of brucellosis. METHODS Biodegradable microspheres made of end-group capped and uncapped poly(lactide-co-glycolide) 50:50 (PLGA 50:50 and PLGA 50:50H) and containing gentam...

2015
Sara Maiolino Annapina Russo Valentina Pagliara Claudia Conte Francesca Ungaro Giulia Russo Fabiana Quaglia

BACKGROUND Novel polymeric nanoparticles (NPs) specifically designed for delivering chemotherapeutics in the body and aimed at improving treatment activity and selectivity, cover a very relevant area in the field of nanomedicine. Here, we describe how to build a polymer shell of Hyaluronan (HA) and Polyethyleneimine (PEI) on biodegradable NPs of poly(lactic-co-glycolic) acid (PLGA) through elec...

2017
Meng Wu Ying Wang Yiru Wang Mingbo Zhang Yukun Luo Jie Tang Zhigang Wang Dong Wang Lan Hao Zhibiao Wang

In the current study, we synthesized prostate cancer-targeting poly(lactide-co-glycolic acid) (PLGA) nanobubbles (NBs) modified using A10-3.2 aptamers targeted to prostate-specific membrane antigen (PSMA) and encapsulated paclitaxel (PTX). We also investigated their impact on ultrasound (US) imaging and therapy of prostate cancer. PTX-A10-3.2-PLGA NBs were developed using water-in-oil-in-water ...

2012
Rajesh Vasita Dhirendra S Katti

BACKGROUND Hydrophobic biopolymers such as polylactide-co-glycolide (PLGA, 85:15) have been extensively explored as scaffolding materials for tissue engineering applications. More recently, electrospun microfiber-based and nanofiber-based scaffolds of PLGA have received increased attention because they act as physical mimics of the fibrillar extracellular matrix. However, the hydrophobicity of ...

2010
Farah Fida

Biosensing Based on Localized Surface Plasmon Resonance of Gold Nanostructures Fabricated by a Novel Nanosphere Lithography Technique

2017
Laura Fernández-Sánchez Irene Bravo-Osuna Pedro Lax Alicia Arranz-Romera Victoria Maneu Sergio Esteban-Pérez Isabel Pinilla María Del Mar Puebla-González Rocío Herrero-Vanrell Nicolás Cuenca

Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of action. The purpose of this work was to assess the efficacy of intravitreal controlled delivery of tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres for the treatment of the retina in a rat ...

Journal: :Journal of biomedical materials research. Part A 2008
Dennis P Link Juliette van den Dolder Jeroen J J P van den Beucken Vincent M Cuijpers Joop G C Wolke Antonios G Mikos John A Jansen

In this study, the biocompatibility of a calcium phosphate (CaP) cement incorporating poly (D,L-lactic-co-glycolic acid) (PLGA) microparticles was evaluated in a subcutaneous implantation model in rats. Short-term biocompatibility was assessed using pure CaP discs and CaP discs incorporating PLGA microparticles (20% w/w) with and without preincubation in water. Long-term biocompatibility was as...

2015
F. Ahmadi K. Derakhshandeh A. Jalalizadeh A. Mostafaie L. Hosseinzadeh

Ovarian cancer is the fifth leading cause of the cancer-related death among women. 9-nitrocamptothecin (9-NC) is a water-insoluble derivative of camptothecin used for the treatment of patients with advanced ovarian cancer. Previous studies showed that the encapsulation of 9-NC in poly (lactic-co-glycolic acid, PLGA) nanoparticles increased the cytotoxic effect of the drug on different cancer ce...

Journal: :journal of research in medical sciences 0
saeid abrishamkar professor, department of neurosurgery, school of medicine, isfahan university of medical sciences, isfahan, iran mostafa torkashvand resident, department of neurosurgery, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran arash momeni borujeni student of master, school of biomaterial (drug delivery system), amirkabir university of technology, tehran, iran amir momani borujeni general practitioner, school of medicine, isfahan university of medical sciences, isfahan, iran majid rezvani assistant professor, department of neurosurgery, school of medicine, isfahan university of medical sciences, isfahan, iran homayon tabesh assistant professor, department of neurosurgery, school of medicine, isfahan university of medical sciences, isfahan, iran

normal 0 false false false en-us x-none ar-sa backgrounds : lumbar disc herniation (ldh) is the most common surgical intervention of spine surgery. during few days of the operation, most patients experience worrying low back pain ( lbp) and radicular leg pain (rlp). applying liquid form of bupivacaine in the vicinity of surgical field could be effective on pain relief only for few hours after o...

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