Result: The study involved 144 patients. Eighty four (58.3%) patients were male and 60(41.7%) patients were female with an age range of 18-78 years and a mean age of 43.5 +/13 SD. Twenty four (16.7%) patients were less than 30 years old, 107(74.3%) patients were between 31-60 years and 13(9%) patients were more than 61 years. Twenty two (15.3%) patients were black and 122(84.7%) were white. Nin...

The objective of this investigation was to determine whether heterogeneity of plasma renin substrate could be observed in states of steroid excess and various forms of hypertensive disease. In states of stimulated renin substrate production by estrogens or glucocorticoids, multiple forms of renin substrate were apparent when stimulation was excessive. Stimulation of substrate production caused ...

The renin-angiotensin system is activated in acute severe asthma. The precise mechanism of activation is at present unknown, but may involve, beta2-agonists, catecholamines or proteases released in airway inflammation. This study aims to identify potential factors involved in the activation of the renin-angiotensin system in acute asthma. Forty asthmatics with severe exacerbations of asthma, as...

Huang, Wan, Mats Sjöquist, Ole Skott, Edward M. Stricker, and Alan F. Sved. Oxytocin-induced renin secretion in conscious rats. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R226–R230, 2000.—Arterial hypotension and hypovolemia are known to stimulate neurohypophysial secretion of oxytocin (OT) in rats, although the physiological function of OT under these circumstances is uncertain...

Aliskiren (Tekturna or Rasilez) is an orally active renin inhibitor approved for the treatment of hypertension.1 As with inhibition of the renin-angiotensin system by angiotensinconverting enzyme inhibitors or type 1 angiotensin II (Ang II) receptor blockers, aliskiren therapy is accompanied by a reactive rise in plasma renin concentration, although in contrast to angiotensin-converting enzyme ...

Cardiopulmonary receptors modulate renin release in several animals species. However, their involvement in reflex control of this humoral substance in humans is controversial. Furthermore, no information is available on the alteration of this control in hypertension. We studied the modulation of plasma renin activity (radioimmunoassay) in 12 normotensive subjects and in 12 age-matched subjects ...

Background: The aim of this study was to investigate the effects of administration of a GnRH analogue to cows with ovarian follicular cysts on plasma renin concentrations and ovarian vascularization. Materials and Methods: This study was performed with 60 Friesian cows, which were diagnosed with follicular cysts, and randomly allocated into two groups: group A (treatment; n = 30) received 2 ml ...

Serial determinations of plasma renin activity, sodium balance, urinary potassium excretion rate, and plasma sodium and potassium concentration were done in five dogs during dietary-induced potassium depletion and repletion. Duration of depletion for the different animals ranged from 5 to 7 wk. Plasma renin activity increased in all animals during depletion, with rises being demonstrated as ear...

In six studies potassium deprivation invariably increased plasma renin activity even though a tendency for sodium retention often accompanied this procedure. The data indicate that both the suppression of plasma renin activity induced by potassium administration and the stimulation of renin activity which follows potassium depletion occur independently of associated changes in either aldosteron...

A striking increase in the plasma renin level occurred in dogs with low output right heart failure secondary to tricuspid insufficiency and pulmonic stenosis and in three of five animals with high output failure produced by a large arteriovenous fistula. When dogs with a small arteriovenous fistula were given daily injections of DOCA, the renal sodium "escape" phenomenon occurred. In these anim...