نتایج جستجو برای: plasma acylcarnitine profile
تعداد نتایج: 564619 فیلتر نتایج به سال:
1. Rat soleus strips were incubated with 5 mM glucose, after which tissue metabolites were measured. Alternatively, muscle strips were incubated with 5 mM glucose and 0.2 mM palmitate, and the formation of 14CO2 from exogenous palmitate or from fatty acids released from prelabelled glycerolipids was measured. 2. Etomoxir, which inhibits the mitochondrial overt form of carnitine palmitoyltransfe...
To identify potential biomarkers for improving diagnosis of melioidosis, we compared plasma metabolome profiles of melioidosis patients compared to patients with other bacteremia and controls without active infection, using ultra-high-performance liquid chromatography-electrospray ionization-quadruple time-of-flight mass spectrometry. Principal component analysis (PCA) showed that the metabolom...
A novel and practical technique for performing both parent and neutral loss (P&NL) monitoring experiments on a quadrupole ion trap mass spectrometer is presented. This technique is capable of performing scans analogous to the parent and neutral loss scans routinely applied on tandem-in-space instruments and allows for the screening of a sample to detect analytes of a specific compound class on ...
Carnitine palmitoyl transferase 2 (CPT-2) is a key enzyme in the mitochondrial fatty acid metabolism. The active site is comprised of a Y-shaped tunnel with distinct binding sites for the substrate acylcarnitine and the cofactor CoA. We investigated the thermodynamics of binding of four inhibitors directed against either the CoA or the acylcarnitine binding sites using isothermal titration calo...
Fatty acids are known to increase the severity of injury during acute myocardial ischemia. In this study, we determined the effects of a carnitine palmitoyltransferase I inhibitor, ethyl 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate (Etomoxir) on reperfusion recovery of fatty acid perfused hearts. Following a 25-minute period of global ischemia, isolated working hearts reperfused with 1.2 m...
In this paper, a theoretical study of electromagnetic wave passing through inhomogeneous over-dense plasma was performed. It was supposed that the plasma layer is immersed in vacuum and the plasma density has aparabolic profileform. In this way, the electric permittivity profile decreases gradually, acquires negative values, and then again becomes positive on the other side of the slab. It has ...
BACKGROUND The amount and type of fat in the diet influence the development of obesity and related inflammatory activity. Knowledge of the possible influence of dietary habits on circulating adiponectin, a molecule with putative antiinflammatory properties, may be helpful in preventing atherosclerosis and type 2 diabetes. METHODS The association between dietary fat, as inferred from plasma fa...
Cardiovascular disease (CVD) continues to be the main cause of morbidity and mortality in the 21st century. As it is almost always more cost-effective to invest in prevention than to cover the treatment costs of most diseases, many governments and institutions consider the prevention of cardiovascular disease to be a main priority of public healthcare systems. This prevention strategy is based ...
1. Daily fluctuations in the plasma concentrations of thyroid stimulating hormone (TSH) and growth hormone (GH) have been studied in six normal males by using a 24 h continuous blood-sampling technique and a highly sensitive and specific radioimmunoassay for TSH. 2. In all subjects the plasma concentrations of the two hormones were increased at night. The TSH concentrations rose approx. 2 h bef...
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