نتایج جستجو برای: plasma acylated ghrelin and pyy3
تعداد نتایج: 16885463 فیلتر نتایج به سال:
Pituitary adenomas comprise a heterogeneous subset of pathologies causing serious comorbidities, which would benefit from identification of novel, common molecular/cellular biomarkers and therapeutic targets. The ghrelin system has been linked to development of certain endocrine-related cancers. Systematic analysis of the presence and functional implications of some components of the ghrelin sy...
Ghrelin, a GH-releasing acylated peptide, has been recently identified from the rat stomach. The purified peptide consists of 28 amino acids in which the serine 3 residue is n-octanoylated. Here we show that ghrelin messenger RNA and ghrelin peptide are present in the human as well as in rat placentae. In human placenta, ghrelin was detected by PCR at both first trimester and after delivery. Wh...
Ghrelin is a peptide hormone that is acylated with a fatty acid, usually n-octanoic acid, at the third amino acid (aa) residue (usually a serine or threonine), and this acylation is known to be essential for ghrelin activity not only in mammals but also in non-mammals, such as fish. However, the modification mechanisms of ghrelin modification in fish are not known. In this study, we elucidated ...
Weight loss induced by endurance exercise is often disappointing, possibly due to an increase in energy intake mediated through greater appetite. The aim of this study was to evaluate fasting, postprandial, and postexercise appetite regulation after an intervention prescribing two amounts of endurance exercise. Sixty-four sedentary, overweight, healthy young men were randomized to control (CON)...
Objectives Ghrelin is a peptide hormone secreted from the endocrine cells of stomach, affecting feeding behavior, appetite, energy consumption, and body weight. The present study compared the effect of 8 weeks of aerobic training on plasma ghrelin and lymphocyte ghrelin gene expression in elderly men. Methods & Materials In this quasi-experimental study, 30 subjects were selected by convenienc...
BACKGROUND Peripheral infusion of glucagon-like peptide 1 (GLP-1) or peptide YY 3-36 (PYY3-36) reduces food intake in healthy, obese, and diabetic subjects. In vivo, both peptides are cosecreted from intestinal L cells; GLP-1 is subject to rapid breakdown by dipeptidyl peptidase IV, and together with PYY3-36 it is likely to be degraded in the liver before entering the systemic circulation. The ...
The ghrelin system comprises acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin, besides the receptor for AG, the growth hormone (GH) secretagogue receptor type 1a (GHS-R1a), and the enzyme-promoting ghrelin acylation, ghrelin O-acyltransferase (GOAT). The ghrelin peptides exert a variety of biological actions, including regulation of energy homeostasis and glucose metabolism, as wel...
W eight loss greater than 6% independently correlates with reduced survival in patients with congestive heart failure (CHF). Cardiac cachexia is a gradual and graded process, with wasting affecting muscle, bone, adipose tissue and the heart. Reduced appetite has been proposed as a important factor for weight loss caused by cardiac cachexia. The mechanism of cardiac cachexia remains largely uncl...
ghrelin is an orexigenic peptide secreted by the stomach. the aim of this study was to investigate the effect of three weeks of endurance training on plasma and fundus ghrelin as well as growth hormone (gh), cortisol hormone and weight in male wistar rats. 20 male wistar rats (14–16 weeks old) were randomly assigned to control (n =10) and training (n=10) groups. the rats in the training group e...
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