BACKGROUND AND PURPOSE Carotid endarterectomy is currently guided by angiographic appearance on the assumption that the most stenotic lesion visible at angiography is likely to be the lesion from which future embolic events will arise. However, risk of plaque rupture, the most common cause of atherosclerosis-related thromboembolism, is dictated by the composition of the plaque, in particular th...

OBJECTIVES This study was performed to evaluate the relationship between plaque inflammation of the initial culprit lesion and the incidence of recurrent angina for one year after directional coronary atherectomy (DCA). BACKGROUND A positive correlation between coronary plaque inflammation and angiographic restenosis has been reported. METHODS A total of 110 patients underwent DCA. Cryostat...

OBJECTIVE Melanocortin peptides have been shown to elicit anti-inflammatory actions and to promote vascular endothelial function by activating type 1 and 3 melanocortin receptors. Here, we addressed whether these favorable properties of melanocortins could reduce atherosclerotic plaque inflammation and improve vasoreactivity in atherosclerotic mice. APPROACH AND RESULTS Low-density lipoprotei...

BACKGROUND AND PURPOSE Treatment with IgG against the malondialdehyde (MDA)-modified apolipoprotein B-100 epitope p45 reduces atherosclerosis in experimental models. This study investigated the association between p45 IgG autoantibodies and plaque inflammation in subjects with advanced cardiovascular disease. METHODS Native and MDA-p45 IgG levels were analyzed by ELISA in 349 carotid endarter...

BACKGROUND AND PURPOSE Watershed ischemia is a significant cause of stroke in severe carotid disease, but its pathophysiology is unsettled. Although hemodynamic compromise has long been regarded as the main mechanism-particularly with deep watershed infarction-there is some contradictory evidence from clinical and pathological studies for a role of microembolism, thought to result from plaque i...

Studies have shown that people with immune diseases, like RA and lupus, have an increased risk of heart attack. Recent research has revealed the role of inflammation in the development and progression of coronary artery disease. Several studies, suggest inflammation causes a sequence of actions in the coronary artery (i.e. plaque rupture, thrombus formation and embolization) to trigger myocardi...

please cite this article as: fayaz a, shakerian m, ansari gh. comparing the efficiency of denture brush and ordinary brush in complete denture cleaning. novel biomed 2013;1(2):62-65. background & objective: denture cleansing is a key element in retaining mucosa free of any inflammation. however, many denture users usually ignore this important factor. this investigation was designed to compare ...

The effect of plaque control on gingivitis and periodontitis is well-documented. In short-term investigations, chemical plaque control (oral rinsing twice a day with 0.2% chlorhexidine-gluconate solution) has been effective in the prevention of human gingivitis. Experimentally produced human gingivitis heals completely within one week when the same method is employed. Tooth cleaning with oral h...

Carotid atherosclerotic plaques are a major cause of ischaemic stroke. The biomechanical environment to which the arterial wall and plaque is subjected to plays an important role in the initiation, progression and rupture of carotid plaques. MRI is frequently used to characterize the morphology of a carotid plaque, but new developments in MRI enable more functional assessment of carotid plaques...

Inflammation and hemostasis are key processes in the pathogenesis of atherosclerotic cardiovascular disease (1,2). Vascular inflammation in response to lipid depositions causes formation of atherosclerotic plaques (1). In addition, inflammation in existing plaques is the primary process responsible for progression toward a phenotype that is vulnerable to rupture and thereby causing acute events...