Background PGD has been around in various forms for over a quarter of a century now. During this time it has evolved from simple FISH and direct PCR mutation analysis to whole chromosome profiling using microarrays or next generation sequencing and improved monogene testing using STR linkage or now, recombination mapping. Modern PGD can now deliver highly accurate and reproducible results capab...

Abstract Nature has been a wellspring of therapeutic operators for a huge number of years and an exceptional number of present day drugs have been secluded from common sources. Higher plants, as wellsprings of restorative mixes, have kept on assuming a prevailing part in the support of human wellbeing since old circumstances. More than half of all cutting edge clinical medications are of...

Recordings of rat hippocampal place cells have provided information about how the hippocampus retrieves memory sequences. One line of evidence has to do with phase precession, a process organized by theta and gamma oscillations. This precession can be interpreted as the cued prediction of the sequence of upcoming positions. In support of this interpretation, experiments in two-dimensional envir...

The hippocampus is essential for spatial navigation, which may involve sequential learning. However, how the hippocampus encodes new sequences in familiar environments is unknown. To study the impact of novel spatial sequences on the activity of hippocampal neurons, we monitored hippocampal ensembles while rats learned to switch from two familiar trajectories to a new one in a familiar environm...

In this paper, we study the problem of designing in-place algorithms for finding the maximum clique in the intersection graphs of axis-parallel rectangles and disks in R2. First, we propose an O(n2 log n) time in-place algorithm for finding the maximum clique of the intersection graph of a set of n axis-parallel rectangles of arbitrary sizes. For the intersection graph of fixed height rectangle...