Some inverse agonists of cannabinoid receptor type 1 (CB1) have been demonstrated to be anorectic antiobesity drug candidates. However, the first generation of CB1 inverse agonists, represented by rimonabant (SR141716A), otenabant, and taranabant, are centrally active, with a high level of psychiatric side effects. Hence, the discovery of CB1 inverse agonists with a chemical scaffold distinct f...

In the trinuclear title compound, [Zn(3)Cl(6)(C(13)H(20)N(4))(2)]·2H(2)O, each terminal Zn(II) atom is coordinated by an N(3) donor set from the Schiff base ligands and two Cl atoms in a distorted square-pyramidal geometry. The central Zn(II) atom is tetra-hedrally coordinated by two piperazine N atoms from two Schiff base ligands and two Cl atoms. The piperazine rings adopt chair conformations...

The asymmetric unit of the title compound, C8H10N6O2, contains one-half mol-ecule, which is completed by a crystallographic center of symmetry. The piperazine ring adopts a chair conformation. In the crystal, weak C-H⋯O inter-actions link the mol-ecules into layers parallel to the bc plane. The crystal packing also exhibits short N⋯N contacts of 3.0467 (16) Å between the terminal diazo N atoms ...

In the title compound, C(17)H(20)Cl(2)N(4)O, the piperazine ring adopts a chair conformation and the dihedral angle between the pyridazine ring and the benzene ring is 36.3 (1)°. In the crystal, weak C-H⋯O and C-H⋯(N,N) inter-actions help to establish the packing, which also features short inter-molecular Cl⋯Cl contacts [3.331 (2) Å].

In the title mol-ecule, C(13)H(18)ClN(3)O, the piperazine ring has a chair conformation. In the crystal, mol-ecules are linked into chains along [100] by N-H⋯O hydrogen bonds.

In the title compound, C(11)H(16)N(4)O(2), the dihedral angle between the benzene ring and the plane of the four carbon atoms in the piperazine ring is 12.17 (3)°; the latter ring adopts a chair conformation. An intramolecular N-H⋯O hydrogen bond generates an S(6) ring. In the crystal, the molecules are linked by N-H⋯N hydrogen bonds, forming chains.