We discuss whether a new paradigm, quantitative systems pharmacology (QSP), based on computational neuroscience modeling combined with proper drug target engagement and pharmacology, human pathology, imaging studies, and calibration and validation using clinical studies in human subjects might improve the success rate of central nervous systems research and development (CNS R&D) projects. We su...

British Journal of PharmacologyVolume 180, Issue S1 p. 1347-1380 ABSTRACTSFree Access Safety Toxicology First published: 27 June 2023 https://doi.org/10.1111/bph.16115AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box below share version article.I have read accep...

British Journal of PharmacologyVolume 180, Issue S1 p. 392-584 ABSTRACTSFree Access Drug Discovery Development First published: 27 June 2023 https://doi.org/10.1111/bph.16107AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms and Conditions Use check box below share version article.I have rea...

British Journal of PharmacologyVolume 180, Issue S1 p. 707-815 ABSTRACTSFree Access Inflammation, Immunology and Infection First published: 27 June 2023 https://doi.org/10.1111/bph.16110AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms Conditions Use check box below share version article.I ...

1 Centre de recherche, Hôpital du Sacré-Cœur de Montréal, Montréal, Canada H4J 1C5 2 Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montréal, Canada H3C 3J7 3 Department of Physiology, Faculty of Medicine, Université de Montréal, Montréal, Canada H3C 3J7 4 Department of Pharmacology, East Tennessee State University, James H. Quillen College of Medicine, Johnson City, T...

a Medical Faculty, Dresden University of Technology, Fetscherstr. 74, Dresden, 01307 Germany b Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences, 6701 Hungary c Department of Pharmacology & Pharmacotherapy, Faculty of Medicine, University of Szeged, Dom ter 12, Szeged, 6701 Hungary d Virginia Commonwealth University, Department of Physiology-Box 980551, Richmond, Virginia 2...

Renal function plays a central role in cardiovascular, kidney, and multiple other diseases, and many existing and novel therapies act through renal mechanisms. Even with decades of accumulated knowledge of renal physiology, pathophysiology, and pharmacology, the dynamics of renal function remain difficult to understand and predict, often resulting in unexpected or counterintuitive therapy respo...

Headache is a common problem which besets most of us at some time or the other. The pharmacology of headache is complex in an overall sense but can be understood in terms of the anatomy and physiology of the pain-producing structures. Migraine can be used as a template to understand the activation of nociceptive systems in the head and thus their neurotransmitter mediation and modulation. In re...

Affiliations: Pharmacology and Toxicology Section, Institute of Pharmacy, University of Bonn, Bonn, Germany (W.K.S, R.S., J.E., T.B., A.B., K.M.); Institute of Physiology I, Life and Brain Center, University Clinic of Bonn, Bonn, Germany (D.W., P.S., B.K.F.); Institute of Pharmacology & Toxicology, University of Bonn, Bonn, Germany (M.W., E.S., K.R.); Department of Pharmaceutical Chemistry, Ins...