We describe the molecular dynamics (MD)-aided engineering design of mutant peptides based on the alpha-helical coiled-coil GCN4 leucine zipper peptide (GCN4-p1) in order to obtain environmentally-responsive nanotweezers. The actuation mechanism of the nanotweezers depends on the modification of electrostatic charges on the residues along the length of the coiled coil. Modulating the solution pH...

The physicochemical properties of bovine prothrombin and of bovine thrombin were previously described in this journal (1, 2). A derivative of bovine prothrombin, autoprothrombin II, has now been obtained in sufficient quality and quantity for study. In this report we describe some of the physicochemical properties of our product, including sedimentation coefficient, diffusion coefficient, intri...

The operating conditions for preparative chromatography, as for any industrial process, must be optimized. Such optimization is based on thorough understanding of process variables and economics. Optimization of the operating conditions is the best justification for detailed study of the fundamentals of nonlinear chromatography. It is difficult to optimize a separation without a clear understan...

The aim of this study was to evaluate the amount and quality of water in the Magdalena-Eslava river system and to propose alternatives for sustainable water use. The system is the last urban river in the vicinity of Mexico City that supplies surface water to the urban area. Historical flow data were analyzed (1973-2010), along with the physicochemical and bacteriological attributes, documenting...

Modern omics disciplines dealing with food flavor focus the analytical efforts on the elucidation of sensory-active compounds, including all possible stimuli of multimodal perception (aroma, taste, texture, etc.) by means of a comprehensive, integrated treatment of sample constituents, such as physicochemical properties, concentration in the matrix, and sensory properties (odor/taste quality, p...

Three sampling campaigns were carried out in rivers located at two hydrographic basins affected by urban and semi-urban areas around the Metropolitan area of A Coruña (ca. 500,000 inhabitants, NW-Spain) to study local and temporal variations of 21 physicochemical parameters (pH, conductivity, Cl-, SO4(2-), SiO2, Ca2+, Mg2+, Na+, K+, hardness, NO3(-), NO2(-), NH4(+), COD, PO4(3-), Zn2+, Cu2+, Mn...

BACKGROUND Efforts are being made to apply physicochemical parameters analysis in the identification of varietal honeys. With many variables describing a given population, it is feasible to differentiate between basing on principal component analysis (PCA). The aim of this study was to investigate selected physicochemical quality characteristics of nectar honey, with particular emphasis paid to...

BACKGROUND AND OBJECTIVES There are several formulations of propofol available to the anesthesiologist for clinical use. The aim of this study was to analyze the physicochemical properties, pharmacodynamic effect, and pharmaceutical and clinical equivalence of the reference drug propofol as well as a similar formulation. METHOD Sixteen volunteers were enrolled in this randomized, double-blind...

The effects of variable moisture content, screw speed and barrel temperature on the physicochemical properties of red ginseng powder extrudates were investigated. The raw red ginseng powders were processed in a co-rotating intermeshing twin-screw extruder. Primary extrusion variables were feed moisture content (20 and 30%), screw speed (200 and 250 rpm) and barrel temperature (115 and 130°C). E...