In this work, we discovered that polypyrrole nanoparticles (PPy NPs) displayed a low non-specific protein adsorption. We herein present the first PPy NP-based biosensing platform for intracellular mRNA detection in living cells. We also demonstrate that PPy NPs exhibit high NIR absorbance and can be utilized for cancer photothermal therapy.

BACKGROUND Theranostic nanomaterials composed of fluorescent and photothermal agents can both image and provide a method of disease treatment in clinical oncology. For in vivo use, the near-infrared (NIR) window has been the focus of the majority of studies, because of greater light penetration due to lower absorption and scatter of biological components. Therefore, having both fluorescent and ...

Breast Cancer Therapy In article number 2201971, Ruibing Wang and co-workers develop supramolecular peptide (based upon the host–guest interaction between cucurbit[7]uril Phe-Phe-Val-Leu-Lys) capped Au nanocages, to allow self-aggregation into micron-sized clusters inside spermine-overexpressed tumor cells, leading specific accumulation retention of nanocages in breast for synergistic photother...

Background: Hepatocellular carcinoma (HCC) is the fifth most common malignancy in world. Surgical intervention remains primary treatment option for resectable liver cancer. However, low curative resection ratio, high metastatic and risk of recurrence make this less than ideal. Additionally, choice transplantation limited by availability donors. This literature review aimed to discuss combinatio...

Hyperspectral microscopy is rapidly developing as an effective tool for characterizing existing FDA approved APIs (active pharmaceutical ingredients) that are being incorporated with nano or micron-scale vectors for targeted drug delivery. It is also utilized extensively to image and characterize nanomaterials used in photothermal therapy and related theranostic studies as well as nanotoxicolog...

A DNA hydrogel is reported as a delivery vehicle for gold nanorods and doxorubicin. The two photothermal and chemo cancer agents were co-loaded using electrostatic and DNA binding interactions, respectively. Light-triggered and highly synergistic combination cancer therapy was demonstrated in cellular and animal models.