To facilitate DNA packaging and photolytic release, o-nitrobenzyl and methacrylate functionalized PEI (P10A) was synthesized for condensing DNA into nanoparticles as small as 160 nm after radical polymerization with initiator. The gene expression following delivery of uncross-linked P10A/DNA was unchanged by photoirradiation of cells. However, exposure to photo-irradiation caused a 3-fold incre...

We develop a semiempirical grey radiative model to quantify Titan's surface temperature as a function of pressure and composition of a nitrogen-methane-hydrogen atmosphere, solar flux and atmospheric haze. We then use this model, together with non-ideal gas-liquid equilibrium theory to investigate the behavior of the coupled surface-atmosphere system on Titan. We find that a volatile-rich Titan...

The slope of the three-isotope plot for the isotopomer fractionation by direct or nearly direct photodissociation is obtained using a perturbation theoretical analysis. This result, correct to first order in the mass difference, is the same as that for equilibrium chemical exchange reactions, a similarity unexpected a priori. A comparison is made with computational results for N2O photodissocia...

An isocratic RP-HPLC method was developed for the determination of Cefditoren pivoxil in pharmaceutical formulations using a C-18 column with water-acetonitrile (50:50, v/v) as mobile phase and flow rate 1.2 mL/min (UV detection at 218 nm). Linearity was observed in the concentration range 1.0-250 μg/mL (R2=0.999) with regression equation y=24194x+10749. The forced degradation studies were perf...

Molecular excitation by the simultaneous absorption of two photons provides intrinsic three-dimensional resolution in laser scanning fluorescence microscopy. The excitation of fluorophores having single-photon absorption in the ultraviolet with a stream of strongly focused subpicosecond pulses of red laser light has made possible fluorescence images of living cells and other microscopic objects...

In the neocortex, the effectiveness of potential transplantation therapy for diseases involving neuronal loss may depend upon whether donor neurons can reestablish the precise long-distance projections that form the basis of sensory, motor, and cognitive function. During corticogenesis, the formation of these connections is affected by tropic factors, extracellular matrix, structural pathways, ...

The photolytic activation of palladium(II) and platinum(II) complexes [M(BPI)(R)] (R = alkyl, aryl) featuring the 1,3-bis(2-pyridylimino)isoindole (BPI) ligand has been investigated in various solvents. In absence oxygen, formation chloro [M(BPI)Cl] is observed chlorinated solvents, most likely due to degradation solvent HCl. reactivity toward oxygen studied both experimentally computationally....

In this paper, we described the properties of a new photolabile group, 2-(3,4-methylenedioxy-6-nitrophenyl)propoxycarbonyl, MNPPOC. In spite of moderate yields of synthesis, photolytic properties could be analyzed for 50-OH protected T and dA. The half-lives (t1/2) 11 and 12 s were found, respectively, with a good recovery of the corresponding deprotected deoxynucleoside (95±99%). The photolysi...