Antiserum specific for influenza A2 neuraminidase was produced by immunization of rabbits with the purified enzyme which had been isolated by electrophoresis from the proteins of a detergent-disrupted AoA2 influenza virus recombinant [X-7 (Fl)]. This recombinant contained hemagglutinin of the Ao subtype and A2 neuraminidase. Antiserum to the isolated A2 neuraminidase did not react in any of fou...

Pancreatic phospholipase A2 and non-pancreatic ascitic phospholipases A2 were studied in sera of healthy individuals and of patients suffering from sepsis or acute pancreatitis. In gel filtration experiments, immunoreactive ascitic phospholipase A2, as determined in serum by a time-resolved fluoroimmunoassay, eluted either unassociated with an apparent M(r) of 10,000-14,000 or associated with p...

The A2 allele of the CYP17 gene has been thought to be associated with increased functional activity of this steroidogenic enzyme. Consequently, the A2 allele has been examined as a biomarker of individual susceptibility to hormone-related diseases among men and women. We prospectively assessed the association between the A2 allele of CYP17 and prostate cancer risk among 590 cases and 782 contr...

This paper has no novel learning or statistics: it is concerned with making a wide class of preexisting statistics and learning algorithms computationally tractable when faced with data sets with massive numbers of records or attributes. It briefly reviews the static AD-tree structure of Moore and Lee (1998), and offers a new structure with more attractive properties: (1) the new structure scal...

While the naive factorization assumption works well for many two-body nonleptonic B meson decay modes, the recent measurement of B̄ → D(∗)0M0 withM = π, ρ and ω shows large deviation from this assumption. We analyze the B → D(∗)M decays in the perturbative QCD approach based on kT factorization theorem, in which both factorizable and nonfactorizable contributions can be calculated in the same fr...

While the factorization assumption works well for many two-body nonleptonic B meson decay modes, the recent measurement of B̄ → D(∗)0M0 with M = π, ρ and ω shows large deviation from this assumption. We analyze the B → D(∗)M decays in the perturbative QCD approach based on kT factorization theorem, in which both factorizable and nonfactorizable contributions can be calculated in the same framewo...

Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical pathway mediating this response is via mTOR inhibition, there are likely to be additional pathways that support the process. Here, we identify Annexin A2 as an autophagy modulator that regulates au...

Let A2(n) denote the quotient of the Siegel upper half space of degree two by ?2(n), the principal congruence subgroup of level n in Sp(4; Z). A2(n) is the moduli space of principally polarized abelian varieties of dimension two with a level n structure, and has a compacti-cation A2(n) rst constructed by Igusa. When n 3 this is a smooth projective algebraic variety of dimension three. In this w...

Resident mouse peritoneal macrophages have three phospholipase activities: a phospholipase A2 active at pH 4.5, a Ca2+-dependent phospholipase A2 active at pH 8.5 and a phosphatidylinositol-specific phospholipase C activity. When macrophages are exposed to zymosan in culture, the cellular activity of pH-4.5 phospholipase A2 is diminished in a manner dependent on zymosan concentration and time o...

This research includes synthesis of new derivatives benzimidazole , the compound (A1*) prepared by reaction o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then was ethyl chloroacetate and hydroxide to give ester (A2*). preparation hydrazide (A3*) (A2*) hydrazine hydrate (80%). we used prepare pyrazole (A4), then mannich basses (A4) different primary aromatic amines ...