The first examples of metal phosphonates based on an asymmetrical 2-(phosphonomethyl)benzoic acid (2-pmbH3) are reported, namely, Co2(μ4-OH)(2-pmb) (1) and Cu4(μ3-OH)2(2-pmb)2 (2). Both crystallize in polar space groups and show layered structures. Compound 1 contains unusual μ4-OH bridged double chains of {Co2(μ4-OH)O3}, inter-connected by the phosphonate groups. In 2, chair-like tetramers of ...

A series of novel chiral thioureas 3a-n bearing leucine and phosphonate moieties were synthesized in excellent yields. The structures of the compounds were completely characterized by elemental analysis, IR, 1H-, 13C-, 31P- and 19F-NMR spectral data. A half-leaf method was used to determine the in vivo protective and curative efficacies of the title products against tobacco mosaic virus (TMV). ...

The cation-independent mannose 6-phosphate receptor (CI-M6PR) is essential for the endocytosis of proteins bearing the mannose 6-phosphate (M6P) recognition marker. This study described the synthesis of M6P and M6S analogs presenting greater affinity for CI-M6PR than their natural compounds. Moreover, the finding of their lack of cytotoxicity for human cells and of their increased stability in ...