BACKGROUND & OBJECTIVES Observation of an increased frequency of an intermediate deficiency of serum alpha1-antitrypsin (α1-AT) in patients with Tropical Pulmonary Eosinophilia (TPE) was earlier reported. Though the possibility of existence of an acquired deficiency was suggested, without phenotyping a hereditary α1-AT deficiency in TPE could not totally be ruled out. In this study, we have don...

Detailed and standardized protocols for plant cultivation in environmentally controlled conditions are an essential prerequisite to conduct reproducible experiments with precisely defined treatments. Setting up appropriate and well defined experimental procedures is thus crucial for the generation of solid evidence and indispensable for successful plant research. Non-invasive and high throughpu...

Reproducible and efficient high-throughput phenotyping approaches, combined with advances in genome sequencing, are facilitating the discovery of genes affecting plant performance. Salinity tolerance is a desirable trait that can be achieved through breeding, where most have aimed at selecting for plants that perform effective ion exclusion from the shoots. To determine overall plant performanc...

Unsupervised phenotyping is about clustering patients into homogeneous groups (“phenotypes”) based on observed clinical features. An open challenge is to provide a principled way to define those patient phenotypes in a simple and clinically meaningful manner. In this work, we tackle this challenge by proposing a nonnegative matrix factorization approach extracting phenotypes as a set of integer...

Surface phenotypic characterization of megakaryoblasts, identified by platelet peroxidase activity, was investigated in four patients who showed increased proliferation of megakaryoblasts: one patient with typical features of acute leukemia, one presenting with acute myelofibrosis, and two with Down's syndrome in whom blasts disappeared spontaneously (transient abnormal myelopoiesis, TAM). MY10...

between idiopathic bronchiectasis (i.e. unidentified aetiology after complete diagnostic workup) and ‘undetermined’ bronchiectasis (i.e. unidentified aetiology with incomplete diagnostic workup) seems more stringent and appropriate than in other publications from the past. Secondly, the proposed groups are related to the underlying aetiology of bronchiectasis, are easily identifiable and provid...

A novel dopamine targeted electrochemical detection strategy has enabled the phenotyping and non-invasive monitoring of human midbrain organoids (healthy Parkinson's diseased), by employing a redox-cycling based microsensor.

Multi-task learning has increased in importance due to its superior performance by multiple different tasks simultaneously and ability perform several using a single model. In medical phenotyping, task labels are costly acquire might contain certain degree of label noise. This decreases the efficiency additional human as auxiliary when applying multi-task phenotyping. this work, we proposed an ...

BACKGROUND AND OBJECTIVE Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of the activity of different CYP isoforms. The objective of this study was to characterize the phenotyping metrics ...