A series of N-substituted-2,4-thiazolidinedione derivatives (TZDs) were prepared via N-alkylation of 2,4-TZD at position 3 using substituted benzyl halides. Synthesized N-substituted-2,4-TZD was then substituted at position 5 with substituted aromatic aldehyde according to Knoevenagel condensation method. Structures of the compounds were elucidated using various spectral techniques viz. I...

Abstract We developed an electrocatalytic reduction of (hetero)aryl halides under mild conditions using a proton exchange membrane (PEM) reactor. This approach allows substituting the halogeno groups on aryl rings to protons by water and electron. Taking advantage this transformation, deuterodehalogenation halides, which forms mono‐deuterated (hetero)aryls, was demonstrated heavy as deuterium s...

VEGFR-2 is a critical target for the treatment of solid tumors. This work represents synthetic approaches to new class fenamate-based derivatives with essential pharmacophoric properties comparable inhibitors. The reaction tolfenamic acid hydrazide substituted phenacyl bromide, and phenylisothiocynate produced novel (TA) (compounds 4 5). molecules were validated using spectroscopic techniques s...

a series of n-substituted-2,4-thiazolidinedione derivatives (tzds) were prepared via n-alkylation of 2,4-tzd at position 3 using substituted benzyl halides. synthesized n-substituted-2,4-tzd was then substituted at position 5 with substituted aromatic aldehyde according to knoevenagel condensation method. structures of the compounds were elucidated using various spectral techniques viz. ir, 1hn...

A rotaxane host system containing a novel halogen bonding (XB) 5-iodo-1,2,3-triazole functionalised pyridinium motif, within its axle component, has been prepared via a ring closing metathesis reaction, using chloride as a template. Proton NMR titration experiments, in competitive 1 : 1 CDCl3-CD3OD solvent media, showed the XB rotaxane selectively bound halides over larger, more basic oxoanions...

Among cross-coupling reactions, the Suzuki-Miyaura transformation stands out because of its practical advantages, including the commercial availability and low toxicity of the required reagents, mild reaction conditions, and functional group compatibility. Nevertheless, few conditions can be used to cross-couple alkyl boronic acids or esters with aryl halides, especially 2-pyridyl halides. Here...

An efficient alumina-supported CuO-catalyzed O-arylation of phenols and aliphatic alcohols with various aryl as well as heteroaryl halides under ligand-free conditions are reported. This protocol provides a variety of diaryl ether and bis-diaryl ether motifs by reacting different aryl/aliphatic halides with differently substituted phenols and saturated alcohols in the presence of a catalytic am...

Selective catalytic synthesis of Z-olefins has been challenging. Here we describe a method to produce 1,2-disubstituted olefins in high Z selectivity via reductive cross-coupling of alkyl halides with terminal arylalkynes. The method employs inexpensive and nontoxic catalyst (iron(II) bromide) and reductant (zinc). The substrate scope encompasses primary, secondary, and tertiary alkyl halides, ...