emostasis is defined as “the stoppage of bleeding, hemorrhage, or blood flow through a blood vessel or body part.” Hemostatic agents improve hemostasis by improving primary hemostasis, stimulating fibrin formation, or inhibiting fibrinolysis. 1 Although transfusion of platelets (PLTs) and hemostatic factors are mainstays of therapy, pharmacologic agents are important adjuncts as blood products ...

Sleep problems with behavioral origins occur in 20 to 30 percent of children and are especially common medical, neurodevelopmental, or psychiatric disorders. Insomnia related learned sleep onset associations is most infants toddlers characterized by prolonged night waking, requiring parental intervention restore sleep. It occurs when the child learns associate falling asleep specific experience...

BACKGROUND Cancer patients are at increased risk for depression compared with individuals with no cancer diagnosis, yet few interventions target depressed cancer patients. METHODS Efficacy of psychotherapeutic and pharmacologic interventions for depression in cancer patients who met an entry threshold for depressive symptoms was examined by meta-analysis. Five electronic databases were system...

INTRODUCTION Although a variety of pharmacologic and non-pharmacologic treatments are effective for insomnia in the general population, insomnia in Parkinson's disease differs in important ways and may need different treatments. No studies have conclusively demonstrated effective insomnia treatments in Parkinson's disease. METHODS We conducted a three-arm six-week randomized pilot study asses...

PURPOSE Pharmacologic vitreolysis is a promising new therapy to improve vitreoretinal surgery and, ultimately, prevent disease by mitigating the contribution of vitreous to retinopathy. The mechanism of action of the agents being developed for pharmacologic vitreolysis remains unclear. The experiments in this thesis test the hypothesis that pharmacologic vitreolysis agents break down vitreous m...