Approximately 60 years ago, the metabolism and disposition of isoniazid, an antituberculosis drug, was one of the earliest demonstrations of pharmacogenetic differences in drug handling that resulted in clinical consequences.2 There were marked differences in excretion of the drug among individuals who were then classified into slow acetylators (SA) and rapid acetylators of isoniazid with SA in...

Pharmacogenetics primarily uses genetic variation to identify subgroups of patients who may respond differently to a certain medication. Since its first description, the field of pharmacogenetics has expanded to study a broad range of cardiovascular drugs and has become a mainstream research discipline. Three principle classes of pharmacogenetic markers have emerged: 1) pharmacokinetic; 2) phar...

Pharmacogenetics is an emerging discipline that attempted to understand the hereditary basis for differences in responsiveness or inter-individual variation to therapeutic agents. It is the study of variability in drug response as a result of heredity factors. The importance for pharmacogenetics for the clinician is to enable optimum therapeutic efficacy, to avoid toxicity of those drugs whose ...

Over the past few years, considerable interest has been paid to the way in which social expectations (hopes, hypes, fears) about new genomic technologies help shape, and in themselves are shaped by, emerging technologies, regulatory regimes and social concerns. In comparison, little attention has been paid to the role of expectations in related, but non-scientific discourses, such as bioethics....

Bartosz Bugaj1*, Katarzyna Bogunia-Kubik2 and Jerzy Świerkot1 Author Affiliations 1Department of Rheumatology Internal Medicine, Wroclaw Medical University, Poland 2Laboratory Clinical Immunogenetics Pharmacogenetics, Hirszfeld Institute Immunology Experimental Therapy, Polish Academy Sciences, Received: January 29, 2022 | Published: February 16, Corresponding author: Bugaj, Department Borowska...