Targeted drug delivery using polymeric nanostructures is an emerging cancer research area, engineered for safer, more efficient, and effective use of chemotherapeutic drugs. A pH-responsive, active targeting delivery system was designed using folic acid functionalized amphiphilic alternating copolymer poly(styrene-alt-maleic anhydride) (FA-DABA-SMA) via a biodegradable linker 2,4-diaminobutyric...

The main objective of this study was to develop mebeverine hydrochloride colon targeted drug delivery system using compression coating technique for effective treatment of irritable bowel syndrome. This work was mainly focused on the formulation & in-vitro evaluation of compression coated tablets of mebeverine hydrochloride with different pH dependent polymers like Eudragit L100-55, hydroxyprop...

The objective of present investigation is to design a sustained release floating microballoons of Metformin HCl using two polymers of different permeability characteristics Cellulose Acetate Butyrate (MW of 16,000) and Eudragit RS 100 (MW of 150,000) using the oil-in-oil emulsion solvent evaporation method. The prepared microballoons were studied for drug release behavior in simulated gastric f...

OBJECTIVE(S) Polyethylenimine (PEI) is a potent non-viral gene delivery carrier. PEI surface charge plays a major role in its condensation ability which in turn is a necessary requirement for high transfection efficiency. As the PEI charge density is dependent on pH, the effect of pH changing PEI on PEI condensation ability, transfection efficiency, and cytotoxicity was investigated. MATERIAL...

Hydrogen-bond acidic polymers are important high affinity materials sensitive to organophosphates in the chemical warfare agent sensor detection process. Interactions between the sensor sensitive materials and chemical warfare agent simulants were studied by inverse gas chromatography. Hydrogen bonded acidic polymers, i.e., BSP3, were prepared for micro-packed columns to examine the interaction...

The adsorption of hydrophobically modified polyacrylic acid (HM-PAAc) has been compared to the adsorption of unmodified polymers by means of reflectometry. The polymers were adsorbed onto a noncharged hydrophobic polystyrene surface. The adsorption kinetics of both types of polymer is the same until a certain surface coverage. Then the unmodified sample shows a saturation while the hydrophobica...

Nascent pectin and glucuronoxylan were prepared from membrane-bound enzymes obtained from pea epicotyls. They had previously been shown to exhibit a proteinand pH-dependent pattern of binding to cell wall ghosts and to xyloglucan extracted from cell walls prepared from pea epicotyls; maximum binding required a pH of 3-4, and the presence of cell wall proteins, namely assemblins. To determine wh...

(2015) The nucleoid as a smart polymer. Science has a close but very complex relationship with technology (Latour, 1987). A simple phenomenon is that technology enables science by offering tools that provide new data or new kinds of data. In other cases, aspects or views of the empirical world may remain invisible until technology builds something that unveils them to the eyes of the scientific...