OBJECTIVE To investigate cross-linked hydrogels prepared via inverse emulsion polymerization to entrap poorly aqueous soluble drugs. Polyethylene glycol cross-linked acrylic polymers were synthesized and the loading and release of curcumin, a model hydrophobic drug, was investigated. METHODS Physicochemical characteristics of hydrogels were studied with (13)C nuclear magnetic resonance, Fouri...

The present review article highlights a specific class of responsive polymer-based hydrogels which are formed through association of oppositely charged polyion segments. The underpinning temporary three-dimensional network is constituted of hydrophilic chains (either ionic or neutral) physically crosslinked by ion pair formation arising from intermolecular polyionic complexation of oppositely c...

The pH sensor exploits the phenomenon of upconversion luminescence and is based on a hydrogel matrix containing (a) nanorods of the NaYF(4):Er,Yb type that can be excited with 980-nm laser light to give a green and red (dual) emission, and (b) a longwave absorbing pH probe that causes a pH-dependent inner filter effect.

In the present paper, attention is paid to synthesis and investigation swelling behavior of a superabsorbent hydrogel composite based on Pectin (Pec) and polyacrylonitrile (PAN) in the presence Kaolin powder. The physical mixture of Pec, Kaolin and PAN were hydrolyzed by NaOH solution to yield H-Pec-poly (sodium acrylate-co-acrylamide)/Kaolin superabsorbent hydrogel composite. A proposed mechan...

The aim of this study was to assess applicative properties of the produced acc. to own prescription dental anti-inflammatory hydrogel with Carbopol 974P. Ketoprofen pharmaceutical availability was tested from hydrogel with Carbopol 974P and to compare - from hydrogels of similar prescription produced on the base of xanthan gum carboxymethylcellulose sodium salt. Very high pharmaceutical availab...

This study evaluated the effectiveness of carboxymethyl cellulose (CMC) hydrogel as a dental gel in delivering hydroxyapatite (HAp) to dentine tubules and reducing/eliminating dental hypersensitivity. The hydrogel was prepared by mixing solutions of CMC/ glycerol and distilled water/sorbitol then modified to contain 0%, 10%, 20% and 30% HAp. The pH of the hydrogels decreased and viscosity incre...

In this paper, a novel gelatin-based hydrogel was synthesized through crosslinking graft copolymerization of methacrylic acid (MAA) onto gelatin, using ammonium persulfate (APS) as a free radical initiator in the presence of methylenebisacrylamide (MBA) as a crosslinker. A proposed mechanism for hydrogel formation was suggested and the structure of the product was established using FTIR spectro...

Delivery systems based on filled hydrogel particles (microgels) can be fabricated from natural food-grade lipids and biopolymers. The potential for controlling release characteristics by modulating the electrostatic interactions between emulsifier-coated lipid droplets and the biopolymer matrix within hydrogel particles was investigated. A multistage procedure was used to fabricate calcium algi...