Background: It has been proposed that the pH of airway lining fluid may regulate the fractional exhaled concentration of nitric oxide (FENO) in respiratory disease. Methods: FENO, exhaled breath condensate (EBC) pH, and EBC concentrations of nitrite plus nitrate (NO2/ NO3) were compared in 12 subjects with stable asthma, 18 with stable cystic fibrosis (CF), and 15 healthy control subjects. Eigh...

The effects of age and caloric restriction on cell proliferation, measured as scheduled DNA synthesis (SDS), were evaluated in primary hepatocyte cultures from control and partially hepatectomized (PH) young to old ad libitum (AL) and caloric-restricted (CR) male Fischer 344 (F344) rats. We reported significant age- or CR-related decreases in SDS in control cultures. PH-induced cultures exhibit...

This paper describes the modelling and control of a pH neutralization process using a Local Linear Model Tree (LOLIMOT) and an adaptive neuro–fuzzy inference system (ANFIS). The Direct and Inverse model building using LOLIMOT and ANFIS structures is described and compared. The direct and inverse models of the pH system are identified based on experimental data for the LOLIMOT and ANFIS structur...

The problems of determining the B–spline form of a C Pythagorean– hodograph (PH) quintic spline curve interpolating given points, and of using this form to make local modifications, are addressed. To achieve the correct order of continuity, a quintic B–spline basis constructed on a knot sequence in which each (interior) knot is of multiplicity 3 is required. C quintic bases on uniform triple kn...

When rats (500 g, male) are exercised on a treadmill, pretreatment with the carbamate physostigmine reduces endurance capacity (run time, RT) and increases the rate of rise of core temperature (heating rate, HR). Because physostigmine is a potential nerve agent pretreatment drug, our objective was to determine whether pharmacological intervention could reverse these decrements in performance an...

Carcinogenicity of phenacetin (PH) to the urinary tract was tested with the use of spontaneously hydronephrosis-bearing rats. In Experiment 1, 55 SD/cShi male rats were fed with 2% PH-containing diet for 85 weeks, and 32 SD/cShi male rats fed basal diet for 85 weeks served as controls. Forty-three of 53 rats fed with PH had renal pelvic carcinoma with lung metastases in three. The mean inductio...

To resist the harsh intrinsic milieu, several lines of defense exist in the stomach. The aim of this study was to investigate the effect of the gastric pathogen Helicobacter pylori on these mechanisms in vivo. We used FVB/N mice expressing human alpha-1,3/4-fucosyl transferase (producing Lewis b epitopes) and inoculated with H. pylori 1. Mice were anesthetized with isoflurane or Hypnorm-midazol...

intravenous chemotherapy is an important mean for the treatment of cancers. infusion phlebitis (ph) is a common and acute complication of chemotherapy. the frequency of ph is about 70% in patients undergoing chemotherapeutic management. it can induce the pain, increase the risk of thrombophlebitis, lead to incomplete follow-up, and thereby, affect the patient’s health status. respecting the gre...