نتایج جستجو برای: pgi

تعداد نتایج: 1108  

Journal: :International journal of molecular medicine 2014
Yunquan Li Guohui Liu Dianqi Cai Baoying Pan Yuese Lin Xuandi Li Shujuan Li Ling Zhu Xinxue Liao Huishen Wang

The hypoxia-induced proliferation of pulmonary artery smooth muscle cells (PASMCs) is the main cause of pulmonary arterial hypertension (PAH), in which oxidative stress, cyclooxygenase (COX)-2 and hydrogen sulfide (H(2)S) all play an important role. In the present study, we aimed to examine the effects of H(2)S on the hypoxia-induced proliferation of human PASMCs (HPASMCs) and to elucidate the ...

2017
Leticia Delgado-Herrera Kathryn Lasch Bernhardt Zeiher Anthony J. Lembo Douglas A. Drossman Benjamin Banderas Kathleen Rosa Christopher Lademacher Rob Arbuckle

BACKGROUND To evaluate the psychometric properties of the newly developed seven-item Irritable Bowel Syndrome - Diarrhea predominant (IBS-D) Daily Symptom Diary and four-item Event Log using phase II clinical trial safety and efficacy data in patients with IBS-D. This instrument measures diarrhea (stool frequency and stool consistency), abdominal pain related to IBS-D (stomach pain, abdominal p...

2006
LLOYD AXELROD

Hypertension is associated with hyperinsulinemia in the presence or absence of obesity or glucose intolerance. Physiological concentrations of insulin decrease the catecholamine-induced production of prostaglandin I, (PGI,; prostacyclin) and PGE,, two potent vasodilators, in adipose tissue, one of the largest organs in the body. This finding suggests that hyperinsulinemia increases peripheral v...

Journal: :Journal of neurotrauma 2009
Magnus Olivecrona Marie Rodling-Wahlström Silvana Naredi Lars-Owe D Koskinen

UNLABELLED Prostacyclin (PGI(2)) is a potent vasodilator, inhibitor of leukocyte adhesion, and platelet aggregation. In trauma the balance between PGI(2) and thromboxane A(2) (TXA(2)) is shifted towards TXA(2). Externally provided PGI(2) would, from a theoretical and experimental point of view, improve the microcirculation in injured brain tissue. This study is a prospective consecutive double-...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2004
Kenji Okajima Naoaki Harada Mitsuhiro Uchiba Masakazu Mori

We previously reported that nitric oxide (NO) derived from endothelial NO synthase (NOS) increased endothelial prostacyclin (PGI(2)) production in rats subjected to hepatic ischemia-reperfusion (I/R). The present study was undertaken to determine whether neutrophil elastase (NE) decreases endothelial production of PGI(2), thereby contributing to the development of I/R-induced liver injury by de...

2014
Todd Hulgan M. Sean Boger Diana H. Liao Grace A. McComsey Christine A. Wanke Alexandra Mangili Sharon L. Walmsley Heather McCreath Ginger L. Milne Stephanie C. Sanchez Judith S. Currier Jordan E. Lake

Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2 (PGE-M), prostacyclin (PGI-M), and thromboxane B2 (TxB2) in HIV-infected wom...

Journal: :Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2010
D D Smith X Tan O Tawfik G Milne D J Stechschulte K N Dileepan

The production of thromboxane A(2) (TXA(2)) and prostacyclin (prostaglandin I(2), PGI(2)) is known to be increased in patients with atherosclerosis. In this study, we evaluated the influence of gender on TXA(2) and PGI(2) production, and their association with the progression of atherosclerosis in apolipoprotein E-null (ApoE(-/-)) mice maintained on a high fat diet for 3 months. En face analyse...

Journal: :The Journal of biological chemistry 2003
Patrick Schmidt Nikolay Youhnovski Andreas Daiber Alina Balan Momo Arsic Markus Bachschmid Michael Przybylski Volker Ullrich

Treatment of bovine aortic microsomes containing active prostacyclin synthase (PGI(2) synthase) with increasing concentrations of peroxynitrite (PN) up to 250 microm of PN yielded specific staining of this enzyme on Western blots with antibodies against 3-nitrotyrosine (3-NT), whereas above 500 microm PN staining of additional proteins was also observed. Following treatment of aortic microsomes...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2004
G D Norata E Callegari H Inoue A L Catapano

OBJECTIVE In endothelial cells, cyclooxygenase-1 (COX-1) and COX-2 both contribute to prostacyclin production. Recent findings suggest that COX-2 contributes significantly to systemic prostacyclin synthesis in humans; whether COX-2 inhibition is related to an increased cardiovascular risk is undergoing debate. HDLs have been shown to increase prostacyclin synthesis, thus in the present study we...

2014
Muneki Igarashi Jun Nagano Ayumi Tsuda Takayoshi Suzuki Jun Koike Tetsufumi Uchida Masashi Matsushima Tetsuya Mine Yasuhiro Koga

In patients with functional upper gastrointestinal disorders such as gastroesophageal reflux disease and functional dyspepsia, the presence of symptoms is thought to occur in the absence of any organic diseases and the mechanisms behind this remain unclear. We therefore examined the relationship between stomach-related biomarker levels and symptoms. Twenty-four outpatients who had taken proton-...

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