نتایج جستجو برای: pgc 1α
تعداد نتایج: 15532 فیلتر نتایج به سال:
Activation of resident and infiltrating immune cells is a central event in training adaptation and other contexts of skeletal muscle repair and regeneration. A precise orchestration of inflammatory events in muscle fibers and immune cells is required after recurrent contraction-relaxation cycles. However, the mechanistic aspects of this important regulation remain largely unknown. We now demons...
هدف از پژوهش حاضر، تعیین تأثیر اجرای HIIT بر بیان ژن PGC-1α در عضلات کند و تند انقباض رتهای نر سالم بود. به همین منظور 12 سر رت نر ویستار به دو گروه کنترل (6=n) و تمرین (6=n) تقسیم شدند. تمرین تناوبی شدید شامل پنج روز و در مجموع هشت هفته بود که از سه تناوب (چهار دقیقه با شدت 90 تا 100 درصد VO2max و دو دقیقه با شدت 50 تا 60 درصد VO2max) تشکیل شد. 24 ساعت پس از آخرین جلسۀ تمرین، عضلۀ باز‌کنندۀ...
EFFECT OF 6 WEEKS ENDURANCE TRAINING WITH QUERCETIN SUPPLEMENTATION ON THE EXPRESSION MITOCHONDRIAL PGC-1Α AND ATF2 GENES IN HIPPOCAMPUS DIABETIC MALE RATS
Background: One of the most important biological pathways involved in maintaining energy homeostasis is the AMPK PGC-1α pathway. Activation of this pathway through exercise can be important in regulating mitochondrial biogenesis processes and maintaining energy balance in diabetics. Therefore, the aim of this study was to investigate the effect of endurance exercise on the content of AMPK and P...
Current therapies for Alzheimer’s disease (AD) are symptomatic and do not target the underlying Aβ pathology and other important hallmarks including neuronal loss. PPARγ-coactivator-1α (PGC-1α) is a transcriptional regulator of metabolic genes, oxidative phosphorylation and mitochondrial biogenesis. We previously reported that PGC-1α also regulates the transcription of BACE1, the main enzyme in...
The purpose of this study was to determine mitochondrial biogenesis-related mRNA expression, binding of transcription factors to the peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC-1α) promoter, and subcellular location of PGC-1α protein in human skeletal muscle following exercise in a hot environment compared with a room temperature environment. Recreationally trained males (...
Sirtuin 1 (SIRT1) regulates numerous neuronal processes, including metabolism, antioxidation and aging, through activation of peroxisome proliferator-activated receptor coactivator 1-α (PGC-1α), an upstream regulator of mitochondrial biogenesis and function. However, the role of SIRT1 in the oxidative stress induced by seizures has yet to be elucidated. The present study aimed to investigate wh...
Prolonged immobilization (IM) causes skeletal muscle atrophy characterized by mitochondrial deterioration and proteolysis. Muscle remobilization (RM) increases reactive oxygen species generation, proinflammatory cytokine expression, and oxidative stress, preventing muscle from quick recovery. Thus, we hypothesized that overexpression of peroxisome proliferator-activated receptor γ coactivator 1...
RATIONALE Mechanisms of angiogenesis in skeletal muscle remain poorly understood. Efforts to induce physiological angiogenesis hold promise for the treatment of diabetic microvascular disease and peripheral artery disease but are hindered by the complexity of physiological angiogenesis and by the poor angiogenic response of aged and patients with diabetes mellitus. To date, the best therapy for...
Currently, obesity is a predominant medical condition and an important risk factor for the development of several diseases, including type 2 diabetes mellitus. Importantly, most research has indicated lipid-induced insulin resistance in skeletal muscles is a key link between the aforementioned pathological conditions. PGC-1α is a prominent regulator of myocellular energy metabolism orchestratin...
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