BACKGROUND Prenatal exposures to polyfluoroalkyl compounds (PFCs) may be associated with adverse changes in fetal and postnatal growth. OBJECTIVE We explored associations of prenatal serum concentrations of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexane sulfonate (PFHxS) with fetal and postnatal growth in girls. METHODS We studied a sample of 447 singleton ...

Perfluorooctane sulfonate (PFOS) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) are two persistent environmental contaminants that are toxic to developing nervous systems, particularly via their disruption of thyroid hormone (TH) function. To investigate whether an interaction existed between PFOS and BDE-47 on TH-mediated pathways, adult female Wistar rats were exposed to 3.2 and 32 mg/kg of ...

OBJECTIVE Potential neurotoxic effects of perfluorinated compounds (PFCs) have been reported in highly exposed animals, but whether these chemicals are neurotoxic in humans is not known. We therefore investigated whether prenatal exposure to perfluorooctanoic acid (PFOA) or perfluorooctane sulfate (PFOS), two of the most prevalent PFCs, are associated with behavioral or coordination problems in...

BACKGROUND Perfluoroalkyl acids (PFAAs) are found globally in wildlife and humans and are suspected to act as endocrine disruptors. There are no previous reports of PFAA levels in adult men from Denmark or of a possible association between semen quality and PFAA exposure. OBJECTIVES We investigated possible associations between PFAAs and testicular function. We hypothesized that higher PFAA l...

BACKGROUND Perfluoroalkyl substances (PFASs) are a group of highly persistent chemicals that are widespread contaminants in wildlife and humans. Exposure to PFAS affects thyroid homeostasis in experimental animals and possibly in humans. The objective of this study was to examine the association between plasma concentrations of PFASs and thyroid stimulating hormone (TSH) among pregnant women. ...

OPPT has been assessing perfluor,inated compounds since 1999. This interest was prompted by reports submitted to the agency describing the toxic properties and widespread presence in the environment, including in human populations, of some of these chemicals. Initial efforts focused on perfluorooctane sulfonate (PFOS), and the assessment of ecological and human health hazards was recently publi...

The levels and congener patterns of HBCDs (hexabromocyclododecanes) and PFCs (perfluorinated compounds) were determined in filter-feeding molluscs collected in 2008 and 2010 along the coasts of mainland France. α-HBCD and PFOS (perfluorooctane sulfonate) were detected in all samples, revealing widespread contamination of the coastal environment by these emerging contaminants. The spatial distri...

Midge larvae (Chironomus riparius) were exposed to sediments from a deposition sampled at a site along the Rhône River (France) downstream of an industrial site releasing various perfluorinated chemicals. This sediment is characterized by high concentrations of perfluoroundecanoic acid (PFUnA) and perfluorotridecanoic acid (PFTrDA) and a low perfluorooctane sulfonate (PFOS) concentration. Conce...

The associations between age, body mass index (BMI), parity, place of residence (coastal or inland) and plasma concentrations of perfluorinated compounds (PFCs) were assessed in a study population from south central Vietnam. The study group consisted of 91 delivering women of varied age (18-40 years) from two different locations (37 urban, 36 rural and 18 with unknown residence). Perfluorooctan...

OBJECTIVES To examine the cross-sectional association between serum perfluorooctanate (PFOA), perfuorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluorohexane sulfonate (PFHxS) concentrations with self-reported memory impairment in adults and the interaction of these associations with diabetes status. DESIGN Cross-sectional study. SETTING Population-based in Mid-Ohio Valle...