Une patiente de 56 ans, diabétique type 2, présentait des épisodes d’hypoglycémies, qui ont persisté après arrêt du traitement antidiabétique. épreuve jeûne authentifie une hypoglycémie organique, à 0,34 g/L, insulinémie 6 mUI/L, peptide C 1,9 ng/mL (normes : 0,5–3,0 ng/mL) et proinsuline 3,72, puis 4,5 pmol/L 1,28–3,84 pmol/L). Aucune lésion n’est retrouvée au scanner ou l’écho-endoscopie. La ...

Intravenous injection of alloxan into rabbits, rats, dogs, monkeys, etc., produces a brief hyperglycemia, then a transient hypoglycemia, which in the case of rabbits is severe enough to cause convulsions and death, unless counteracted by repeated injections of glucose, and finally a permanent diabetic hyperglycemia. The cause of the transient hypoglycemia has had various explanations. Goldner a...

BACKGROUND In insulin-requiring type 2 diabetes patients, current insulin therapy approaches such as basal-alone or basal-bolus multiple daily injections (MDI) have not consistently provided achievement of optimal glycemic control. Previous studies have suggested a potential benefit of continuous subcutaneous insulin infusion (CSII) in these patients. The OpT2mise study is a multicenter, random...

Literature data on epidemiology, mechanisms of development, features the course cognitive disorders in type 2 diabetes mellitus (T2DM), as well prospects for their treatment and prevention were analyzed. Diabetes is recognized an independent factor impairment associated with increased risk dementia, main causes which are Alzheimer’s disease vascular dementia. Results recent research have shown ...

BACKGROUND In patients with late dumping syndrome following gastrectomy, it has been reported that hypoglycemia occurs due to inhibition of glucagon secretion as a result of excessive insulin production facilitated by an increase in glucagon-like peptide-1 (GLP-1). METHODS To determine the kinetics of incretins in Japanese patients with late dumping syndrome, an oral glucose tolerance test wa...

Inpatient Glycemic Targets After publication of the initial van den Berghe trial in surgical intensive care patients,1 several professional organizations published guidelines supporting near-normal glycemic targets.8,9 Subsequent trials documented an increased risk for hypoglycemia with tight glycemic control, suggesting that more modest glycemic targets may be optimal.10–13 The Normoglycemia i...

Inactivating MEN1 mutations are the most common genetic defects present in sporadic and inherited pancreatic neuroendocrine tumours (PNETs). The lack of interventional therapies prompts us to explore the therapeutic approach of targeting β-catenin signalling in MEN1-mutant PNETs. Here we show the MEN1-encoded scaffold protein menin regulates phosphorylation of β-catenin. β-catenin signalling is...

ATP-sensitive K+ (KATP) channels are known to play important roles in various cellular functions, but the direct consequences of disruption of KATP channel function are largely unknown. We have generated transgenic mice expressing a dominant-negative form of the KATP channel subunit Kir6.2 (Kir6.2G132S, substitution of glycine with serine at position 132) in pancreatic beta cells. Kir6.2G132S t...

Patients who are critically ill can develop acute insulin resistance manifesting as hyperglycemia and hyperinsulinemia. Rarely, patients can develop extreme insulin resistance, defined as having an insulin requirement of >3 units/kg/day (1). We report here a case of a septic patient who developed acute extreme insulin resistance in the critical care setting that was difficult to treat, and afte...