نتایج جستجو برای: peroxisome proliferator
تعداد نتایج: 15330 فیلتر نتایج به سال:
Note: The PPAR gamma gene, a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear hormone receptors, is implicated in adipocyte differentiation and function. In order to regulate the transcription of target genes, the PPAR protein needs to form heterodimers with retinoid X receptors (RXRs). Three splice variants of PPAR gamma are known: PPAR gamma1, PPAR gamma2, ...
Osteoarthritis (OA) is among the most prevalent chronic human health disorders and the most common form of arthritis. It is a leading cause of disability in developed countries. This disease is characterized by cartilage deterioration, synovitis, and remodeling of the subchondral bone. There is not yet a satisfactory treatment to stop or arrest this disease process. Although several candidates ...
in this presentation, we review briefly on biogenesis of peroxisomes with regard to the recent findings on biogenesis. peroxisomes perform a range of various functions as oxidation of very long chain fatty acids, generation and removal of hydrogen peroxide, while peroxisomes have also been implicated in β-oxidation of aromatic and cyclic compounds, synthesis of plasmalogens, isoprenoids, lysine...
Submit Manuscript | http://medcraveonline.com Abbreviations: ALT: Alanine Transaminase; AST: Aspartate Amino Transferase; CIMT: Carotid Intima Media Thickness; CYP450: Cytochrome P450; DHA: Docosahexaenoic Acid; DM: Diabetes Mellitus; EPA: Eicosapentaenoic Acid; FA: Fatty Acids; HF: High Fat; HNE: 4-Hydroxy-2-Nonenal; MDA: Malondialdehyde; mtDNA: Mitochondrial DNA; n-3 PUFAs: n-3 Polyunsaturate...
A series of novel derivatives of the nonsteroidal anti-inflammatory drug (NSAID) sulindac sulfide were synthesized as potential agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma). Nonpolar and aromatic substitutions on the benzylidene ring as well as retention of the carboxylic acid side chain were required for optimal activity. Compound 24 was as potent a compound as ...
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